Prof. Ton G. van Leeuwen
Full Professor/Chairman of Department at Amsterdam UMC
SPIE Involvement:
Conference Program Committee | Editorial Board Member: Journal of Biomedical Optics | Author | Editor
Area of Expertise:
optical coherence tomography , photo-acoustic imaging , spectroscopy
Profile Summary

Ton van Leeuwen graduated in physics at the University of Amsterdam in 1989. After his PhD and post doc at the Lab. for Exp. Cardiology at the UMC Utrecht and an ICIN fellowship at CWRU (Cleveland), he became staff member of the Laser Center at the AMC. In 2001, Ton was appointed as professor in Clinical Application of Biomedical Optics at the University of Twente, at which he headed the Biomedical Optics group from 2003 - 2008. In 2008 he was appointed as professor in Biomedical Photonics and head of the new BME & Physics department at the Academic Medical Center of the University of Amsterdam. In 2009, he was appointed as full professor in Biomedical Physics.
Current research focuses on the physics of the interaction of light with tissue, and to use that knowledge for the development, introduction and clinical evaluation of (newly developed) optical imaging techniques for gathering quantitative functional and molecular information of tissue.

The research is structured along the following research lines:
The use of the intrinsic contrast of OCT is explored for the in vivo staging and grading of tumors;
Novel OCT signal analysis to determine blood velocity profiles, perfusion and diffusion and relate this information to pathology;
The integration and combination of different imaging technologies (e.g. OCT and CT, (Raman) spectroscopy and OCT);
Hyper-spectral monitoring and imaging to assess the concentration of blood and blood derivatives as bilirubin, met-, deoxy- and oxyhemoglobin in the skin (for age determination of bruises) and hemichrome (for ex-vivo blood-stain analysis);
New optical techniques for the detection of microvesicles in blood plasm as a "liquid biopsy";
Novel photonic devices, based on minimally invasive designs and integrated optics, which are suitable for small and dedicated monitoring and imaging devices in the clinic ("cleanroom to clinic")
Publications (139)

SPIE Journal Paper | 3 April 2020
JBO Vol. 25 Issue 04
KEYWORDS: Optical coherence tomography, Signal attenuation, Tissues, Scattering, Tissue optics, Light scattering, Skin, Optical properties, Absorption, Cancer

Proceedings Article | 1 April 2020
Proc. SPIE. 11362, Clinical Biophotonics

Proceedings Article | 9 March 2020
Proc. SPIE. 11238, Optical Interactions with Tissue and Cells XXXI
KEYWORDS: Modeling, Scattering, Photons, Reflectivity, Monte Carlo methods, Reflectance spectroscopy, Absorption

SPIE Journal Paper | 9 January 2020
JBO Vol. 25 Issue 01
KEYWORDS: Reflectivity, Scattering, Photons, Tissues, Reflectance spectroscopy, Monte Carlo methods, Tissue optics, Spectroscopy, Absorption, Optical properties

SPIE Journal Paper | 9 December 2019
JBO Vol. 24 Issue 12
KEYWORDS: Skin, Scattering, Absorption, Tissue optics, Reflectivity, Reflectance spectroscopy, Rayleigh scattering, Optical properties, Photons, Light scattering

Showing 5 of 139 publications
Proceedings Volume Editor (2)

SPIE Conference Volume | 4 October 2019

SPIE Conference Volume | 11 September 2017

Conference Committee Involvement (8)
Clinical Biophotonics
6 April 2020 | Online Only, France
Preclinical and Clinical Optical Diagnostics
23 June 2019 | Munich, Germany
Clinical and Preclinical Optical Diagnostics
25 June 2017 | Munich, Germany
Optical Coherence Tomography and Coherence Techniques V
24 May 2011 | Munich, Germany
Optical Coherence Tomography and Coherence Techniques
17 June 2007 | Munich, Germany
Showing 5 of 8 Conference Committees
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