Prof. Ton G. van Leeuwen
Full Professor/Chairman of Department at Amsterdam UMC
SPIE Involvement:
Fellow status | Senior status | Conference Chair | Conference Program Committee | Journal Editorial Board Member | Author | Editor
Area of Expertise:
optical coherence tomography , photo-acoustic imaging , spectroscopy
Profile Summary

Ton van Leeuwen graduated in physics at the University of Amsterdam in 1989. After his PhD and post doc at the Lab. for Exp. Cardiology at the UMC Utrecht and an ICIN fellowship at CWRU (Cleveland), he became staff member of the Laser Center at the AMC. In 2001, Ton was appointed as professor in Clinical Application of Biomedical Optics at the University of Twente, at which he headed the Biomedical Optics group from 2003 - 2008. In 2008 he was appointed as professor in Biomedical Photonics and head of the new BME & Physics department at the Academic Medical Center of the University of Amsterdam. In 2009, he was appointed as full professor in Biomedical Physics.
Current research focuses on the physics of the interaction of light with tissue, and to use that knowledge for the development, introduction and clinical evaluation of (newly developed) optical imaging techniques for gathering quantitative functional and molecular information of tissue.

The research is structured along the following research lines:
The use of the intrinsic contrast of OCT is explored for the in vivo staging and grading of tumors;
Novel OCT signal analysis to determine blood velocity profiles, perfusion and diffusion and relate this information to pathology;
The integration and combination of different imaging technologies (e.g. OCT and CT, (Raman) spectroscopy and OCT);
Hyper-spectral monitoring and imaging to assess the concentration of blood and blood derivatives as bilirubin, met-, deoxy- and oxyhemoglobin in the skin (for age determination of bruises) and hemichrome (for ex-vivo blood-stain analysis);
New optical techniques for the detection of microvesicles in blood plasm as a "liquid biopsy";
Novel photonic devices, based on minimally invasive designs and integrated optics, which are suitable for small and dedicated monitoring and imaging devices in the clinic ("cleanroom to clinic")
Publications (129)

SPIE Journal Paper | August 9, 2018
JBO Vol. 23 Issue 08
KEYWORDS: Optical coherence tomography, Tissues, Prostate, Signal attenuation, Prostate cancer, Visualization, Tissue optics, Inflammation, Quantitative analysis, Visual analytics

SPIE Journal Paper | April 12, 2018
JBO Vol. 23 Issue 04
KEYWORDS: Optical coherence tomography, Esophagus, Tissues, Scattering, Computed tomography, In vivo imaging, Visualization, Animal model studies, Lung cancer, Collagen

PROCEEDINGS ARTICLE | March 15, 2018
Proc. SPIE. 10492, Optical Interactions with Tissue and Cells XXIX
KEYWORDS: Fiber optics, Optical properties, Calibration, Light scattering, Reflectivity, Diagnostics, Spectral calibration, Reflectance spectroscopy, Tissue optics, Spectroscopes

PROCEEDINGS ARTICLE | March 14, 2018
Proc. SPIE. 10487, Multimodal Biomedical Imaging XIII
KEYWORDS: Optical imaging, Tissues, Imaging systems, Stereoscopy, Luminescence, Image resolution, Multispectral imaging, Molecular imaging, 3D image processing, Bandpass filters

PROCEEDINGS ARTICLE | February 14, 2018
Proc. SPIE. 10483, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXII
KEYWORDS: Mirrors, Visible radiation, Waveguides, Interferometers, Optical coherence tomography, Spectroscopy, Silicon, Spectral resolution, Photonic integrated circuits

SPIE Journal Paper | February 12, 2018
JMI Vol. 5 Issue 01
KEYWORDS: Optical coherence tomography, Tumors, Computed tomography, Visualization, Ultrasonography, 3D image processing, Diagnostics, Biopsy, Image resolution, Imaging systems

Showing 5 of 129 publications
Conference Committee Involvement (7)
Preclinical and Clinical Optical Diagnostics
23 June 2019 | Munich, Germany
Clinical and Preclinical Optical Diagnostics
25 June 2017 | Munich, Germany
Optical Coherence Tomography and Coherence Techniques V
24 May 2011 | Munich, Germany
Optical Coherence Tomography and Coherence Techniques
17 June 2007 | Munich, Germany
Optical Coherence Tomography and Coherence Techniques II
12 June 2005 | Munich, Germany
Showing 5 of 7 published special sections
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