Iterative reconstruction is a good match with the sparsely sampled limited angle data generated by breast tomosynthesis systems. However, it suffers from a specific artifact near the breast edge where it overestimates the x-ray path length, resulting in a considerable underestimation of the reconstructed linear attenuation coefficients. In this work, we present the application of a method that uses the measured 3D breast shape to reduce these artifacts in patient data, by including this information as an additional constraint in the image reconstruction process. A series of 50 patients undergoing breast tomosynthesis were additionally imaged with a pair of structured light cameras placed left and right of the mammography unit. These 3D surfaces were then aligned with the help of the backprojected breast outline from the x-ray data to form a single contour following the true breast shape. This was then further processed to generate a binary 3D mask set to 1 inside and to 0 outside the breast, and used as constraint in the reconstruction. Due to incomplete coverage and image artifacts, this mask was created successfully for only 19 out of 50 cases. Reconstructions were created with and without this constraint, and comparing attenuation profiles found that the artifact was almost completely corrected, bringing the reconstructed attenuation near the breast edge to the same level as the central region. Further visual inspection does show that higher quality optical 3D measurements and more precise alignment between optical and x-ray data are needed to avoid introducing new artifacts in the reconstruction.