Photostimulation using Au and Si-based nanomaterials has shown promise for optical stimulation of cells. However, these methods still suffer from key limitations: the need for high laser power, low thermal conversion efficiency, and unproven long-term stability. We report a breakthrough hybrid-nanomaterial for remote and non-genetic light-induced control of targeted cell activity. We combine one-dimensional (1D) nanowires (NWs) and two-dimensional (2D) graphene flakes grown out-of-plane with tailor-made physical properties for highly controlled photostimulation. Photostimulation using NW templated 3D fuzzy graphene (NT-3DFG) is flexible due to its broadband absorption and does not generate cellular stress. Our light-based platform adds a powerful toolset to the basic scientists studying cell signaling within and between tissues.