The applications of lasers in medicine, both in the field of diagnosis and treatment are gaining momentum. In dentistry in
particular, numerous types of lasers with a wide range of characteristics are being utilized in all fields. In consequence, a
lot of experience and knowledge has been gained in the last two decades in this domain; this resulted in the development
of novel technologies and devices. A brief overview is made in the first part of this article on these topics. The treatment
of periodontal disease with laser therapy is pointed out, as well as the photodynamic therapy which is using LLLT for the
activation of the sensitizing gel that is introduced in the periodontal pockets. This paper reviews also the application of
photodynamic therapy in clinical trials which have different results; a standardization of the protocol utilized for this
procedure is concluded to be necessary.