Ms. Vitoria V. Maciel Profile

Vitoria V. Maciel

at Instituto de Fisica de Sao Carlos

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Proceedings Article | 13 July 2009 Paper

Fluorescence diagnosis in tissue injury

Vitória Maciel, Juliana Ferreira, Vanderlei Bagnato

Proceedings Volume 7380, 73805B (2009) https://doi.org/10.1117/12.823019

KEYWORDS: Skin, Luminescence, Ultraviolet radiation, Tissues, Injuries, Skin cancer, Fluorescence spectroscopy, Tissue optics, Cancer, Lamps

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Background and Objectives: The paper aim was to evaluate the efficacy of the fluorescence spectroscopy in the detection of UV-induced skin change of Wistar rats. Study Design/ Materials and Methods: In a group male Wistar rats, the skin damage was produced by an UV-C lamp, periodically monitored using the laser-induced fluorescence, until complete healing process. After determining a characteristic emission band present in the fluorescence spectra of the induced injuries, the amplitude band monitoring allowed the follow up on the injury and the recovery. Results: We observed the appearance of two new emission bands more evident at the injury spectra when compared to the spectrums from normal non-exposed tissue. Following such spectral bands was possible to observe the establishment and recovery. Conclusions: The fluorescence spectroscopy is a promising technique in distinguishing between normal and UV induced skin change helping the evaluation of changes which are irreversible cancer tissue characteristics.

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