Wei-Chuan Shih earned his Ph.D. from MIT Spectroscopy Laboratory/NIH Laser Biomedical Research Center under late laser physicist Dr. Michael S. Feld, studying novel optical spectroscopy techniques for non-invasive chemical/biomedical sensing and disease diagnosis. He also worked extensively on MEMS design and nanofabrication. Prior to joining the U. of Houston, he was Schlumberger research fellow, studying optical analysis of hydrocarbon and offshore oil spill monitoring.
He was MIT Martin Fellow of Sustainability, and won NSF CAREER Award in Biophotonics, inaugural NASA Early CAREER Faculty Award, UH Award for Excellence in Research and Scholarship, UH Cullen College of Engineering Faculty Research Excellence Award, and Cullen College Rising Innovator Award. Dr. Shih has served as Associate Editor of OSA Applied Optics and SPIE Journal of Nanophotonics. He has been elected Senior Member (Inaugural class 2019) of National Academy of Inventors. He is also Senior Member of IEEE, OSA, and SPIE.
Dr. Shih’s primary scientific contribution is in biophotonic chem/biosensing and imaging from various aspects such as optical instrumentation, analytics, micro/nanofabrication and plasmonics. Dr. Shih has published more than 120 articles in the public domain (including 68 peer-reviewed journal papers and 5 invited book chapters). Among the 68 journal articles, 58 were published based on his work at UH, 53 corresponding author, and 50 involved his students. He has 11 issued and 6 pending US patents. As of January 2020, he has an H-index 30 (Google Scholar). Dr. Shih has delivered 60 invited seminar/lectures and 109 conference presentations including invited talks at SPIE Photonics West, SPIE Optics & Photonics, SPIE Defense & Commercial Sensing, OSA Biophotonics Congress, ACS meetings, ECI Advances in Optics, IEEE Photonics Conference, IEEE OMN, IEEE NANOMED, PittCon, SciX/FACSS, META, and etc.
He was MIT Martin Fellow of Sustainability, and won NSF CAREER Award in Biophotonics, inaugural NASA Early CAREER Faculty Award, UH Award for Excellence in Research and Scholarship, UH Cullen College of Engineering Faculty Research Excellence Award, and Cullen College Rising Innovator Award. Dr. Shih has served as Associate Editor of OSA Applied Optics and SPIE Journal of Nanophotonics. He has been elected Senior Member (Inaugural class 2019) of National Academy of Inventors. He is also Senior Member of IEEE, OSA, and SPIE.
Dr. Shih’s primary scientific contribution is in biophotonic chem/biosensing and imaging from various aspects such as optical instrumentation, analytics, micro/nanofabrication and plasmonics. Dr. Shih has published more than 120 articles in the public domain (including 68 peer-reviewed journal papers and 5 invited book chapters). Among the 68 journal articles, 58 were published based on his work at UH, 53 corresponding author, and 50 involved his students. He has 11 issued and 6 pending US patents. As of January 2020, he has an H-index 30 (Google Scholar). Dr. Shih has delivered 60 invited seminar/lectures and 109 conference presentations including invited talks at SPIE Photonics West, SPIE Optics & Photonics, SPIE Defense & Commercial Sensing, OSA Biophotonics Congress, ACS meetings, ECI Advances in Optics, IEEE Photonics Conference, IEEE OMN, IEEE NANOMED, PittCon, SciX/FACSS, META, and etc.
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Abnormally shaped red blood cells (RBCs), called poikilocytes, can cause anemia. At present, the biochemical abnormalities in poikilocytes are not well understood. Normal RBCs and poikilocytes were analyzed using whole-blood and single-cell methods. Poikilocytes were induced in rat blood by intragastrically administering titanium dioxide (TiO2) nanoparticles. Complete blood count and inductively coupled plasma mass spectrometry analyses were performed on whole-blood to measure average RBC morphology, blood hemoglobin (HGB), iron content, and other blood parameters. Follow-up confocal Raman spectroscopy was performed on single RBCs to analyze cell-type-specific HGB content. Two types of poikilocytes, acanthocytes and echinocytes, were observed in TiO2 blood samples, along with normal RBCs. Acanthocytes (diameter 7.7 ± 0.5 μm) and echinocytes (7.6 ± 0.6 μm) were microscopically larger (
Nanoporous gold nanoparticle (NPG-NP) array chip showcases tunable pore and ligament sizes ranging from nanometers to microns. The nanoporous structure and sub-wavelength nanoparticle shape contribute to its unique LSPR properties. NPG-NP features large specific surface area and high-density plasmonic field enhancement known as “hot-spots”. Hence, NPG-NP has found many applications in nanoplasmonic sensor development. In our recent studies, we have shown that NPG-NP array chip can be utilized for high-sensitivity detection by various enhanced spectroscopic modalities, as photothermal agents, and for disease biomarker detection. In this paper, we show the first experimental demonstration of effective and robust surface-enhanced near-infrared absorption (SENIRA) on NPG-NP array chip.
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