Dr. Wei-Chung Cheng Profile

Dr. Wei-Chung Cheng

General Engineer at US Food and Drug Administration

SPIE Involvement:

Conference Program Committee | Author

Proceedings Article | 15 February 2021 Presentation + Paper

Spatiotemporal characteristics of medical extended-reality systems

Andrea Kim, Aldo Badano, Ryan Beams, Wei-Chung Cheng

Proceedings Volume 11599, 1159906 (2021) https://doi.org/10.1117/12.2580736

KEYWORDS: Visualization, Sensors, Ultrasonography, Radiography, Magnetism, Medical imaging, Augmented reality, Medical devices, Head-mounted displays, Sensor technology

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Proceedings Article | 15 February 2021 Presentation + Paper

Colorimetrical evaluation of color normalization methods for H&E-stained images

Wei-Chung Cheng, Jocelyn Liu, Samuel Lam, Paul Lemaillet

Proceedings Volume 11603, 116030U (2021) https://doi.org/10.1117/12.2582281

KEYWORDS: Principal component analysis, Visualization, Tissues, Image processing, Scanners, Pathology, Diagnostics, Transmittance

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Proceedings Article | 16 March 2020 Paper

Characterization of color normalization methods in digital pathology whole slide images

Weijie Chen, Dorsa Ziaei, Wei-Chung Cheng, Samuel Lam, Weizhe Li

Proceedings Volume 11320, 1132017 (2020) https://doi.org/10.1117/12.2550585

KEYWORDS: Scanners, Pathology, Color difference, Artificial intelligence, Algorithm development

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The color rendering of whole-slide images (WSIs) depends on factors involving the sample, such as tissue type, preparation methods, staining type and staining protocol, as well as equipment, such as the WSI scanner, WSI viewer, and WSI display. Variations in any of these steps may change the color rendering and therefore affect the performance of pathologists in the interpretation of WSIs and the robustness of artificial intelligence algorithms. In the literature, color normalization techniques have been proposed to reduce the color variations. The purpose of this work is to develop an objective approach to characterizing color normalization methods used in digital pathology. We employed color normalization methods to normalize the color rendered by a WSI scanner and then compared the normalized color with the actual scan by that scanner. The normalization errors were evaluated on the pixel level using the CIE color difference ΔE metric that have been shown to correlate with visually perceived differences in human vision. A selected set of 310 patch images of breast tissues scanned by two scanners from the ICPR 2014 MITOS & ATYPIA contest was used. Images from one scanner were color normalized to match the color rendering of the other scanner. Four color normalization methods were compared – Macenko, Reinhard, Vahadane, and StainGAN. Experimental results show that average color differences between two scanners in terms of ΔE were reduced from 16.2 before normalization to the range of [13.7,16.9] after normalization for the Macenko, Reinhard, Vahadane methods, and to 8.3 for the StainGAN method. Apparently the StainGAN method is significantly superior to the other three methods in terms of the ΔE metric. As such, we demonstrated a quantitative method for objectively evaluating color normalization techniques. Future work is needed to explore the relationship of the color fidelity measure and the impact of color normalization on pathologist and AI performance in clinical tasks.

Proceedings Article | 1 March 2017 Paper

Evaluating color performance of whole-slide imaging devices by multispectral-imaging of biological tissues

Firdous Saleheen, Aldo Badano, Wei-Chung Cheng

Proceedings Volume 10140, 101400R (2017) https://doi.org/10.1117/12.2254997

KEYWORDS: Optical microscopes, Light sources, Tissues, Pathology, Skin, Imaging devices, Multispectral imaging, Color difference, Transmittance, Kidney, Human vision and color perception, Colon, Color reproduction

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SPIE Journal Paper | 9 May 2016 Open Access

Development of the local magnification method for quantitative evaluation of endoscope geometric distortion

Quanzeng Wang, Wei-Chung Cheng, Nitin Suresh, Hong Hua

JBO, Vol. 21, Issue 05, 056003, (May 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.5.056003

KEYWORDS: Distortion, Endoscopes, Lawrencium, Standards development, Endoscopy, Image sensors, Data centers, Image processing, Monochromatic aberrations, Image analysis

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Proceedings Article | 18 March 2015 Paper

Comparison of methods for quantitative evaluation of endoscopic distortion

Quanzeng Wang, Viraj Desai, Kurt Castro, Wei-Chung Cheng, Joshua Pfefer

Proceedings Volume 9412, 94123A (2015) https://doi.org/10.1117/12.2082077

KEYWORDS: Endoscopy, Distortion, Image analysis, Endoscopes, Medical imaging, Image quality, Optical proximity correction, Ruthenium, Standards development, Image quality standards

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SPIE Journal Paper | 12 November 2014 Open Access

Evaluation environment for digital and analog pathology: a platform for validation studies

Brandon Gallas, Marios Gavrielides, Catherine Conway, Adam Ivansky, Tyler Keay, Wei-Chung Cheng, Jason Hipp, Stephen Hewitt

JMI, Vol. 1, Issue 03, 037501, (November 2014) https://doi.org/10.1117/12.10.1117/1.JMI.1.3.037501

KEYWORDS: Microscopes, Image registration, Cameras, Pathology, Analog electronics, Glasses, Reticles, MATLAB, Tissues, Imaging systems

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Proceedings Article | 11 March 2014 Paper

eeDAP: an evaluation environment for digital and analog pathology

Wei-Chung Cheng, Adam Wunderlich, Adam Ivansky, Tyler Keay, Brandon Gallas, Marios Gavrielides, Jason Hipp, Stephen Hewitt

Proceedings Volume 9037, 903709 (2014) https://doi.org/10.1117/12.2044443

KEYWORDS: Microscopes, MATLAB, Reticles, Tissues, Cameras, Glasses, Pathology, Image registration, Transmittance, Analog electronics

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Proceedings Article | 31 December 2013 Paper

Towards standardized assessment of endoscope optical performance: geometric distortion

Quanzeng Wang, Viraj Desai, Ying Ngo, Wei-Chung Cheng, Joshua Pfefer

Proceedings Volume 9042, 904205 (2013) https://doi.org/10.1117/12.2044103

KEYWORDS: Endoscopy, MATLAB, Distortion, Image analysis, Endoscopes, Image quality, Optical proximity correction, Geometrical optics, Standards development, Image quality standards

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Proceedings Article | 29 March 2013 Paper

Assessing color reproducibility of whole-slide imaging scanners

Wei-Chung Cheng, Tyler Keay, Neil O'Flaherty, Joel Wang, Adam Ivansky, Marios Gavrielides, Brandon Gallas, Aldo Badano

Proceedings Volume 8676, 86760O (2013) https://doi.org/10.1117/12.2007215

KEYWORDS: Light sources, Imaging systems, Glasses, Scanners, Photography, Field programmable gate arrays, Digital imaging, Color difference, Transmittance, Color management

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Proceedings Article | 7 March 2012 Paper

Evaluating color calibration kits with virtual display

Aldo Badano, Hugo Caceres, Wei-Chung Cheng

Proceedings Volume 8292, 82920A (2012) https://doi.org/10.1117/12.909660

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Proceedings Article | 7 March 2012 Paper

Impact of solid-state lighting on observer performance of color discrimination

Widad Tannous, Aldo Badano, Wei-Chung Cheng

Proceedings Volume 8318, 83181T (2012) https://doi.org/10.1117/12.912436

KEYWORDS: Light sources, Light emitting diodes, Visualization, Solid state lighting, Tungsten, Photography, Lamps, Light sources and illumination, Color vision, Halogens

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Proceedings Article | 3 March 2010 Paper

A gaze-contingent high-dynamic range display for medical imaging applications

Aldo Badano, Wei-Chung Cheng

Proceedings Volume 7627, 76270A (2010) https://doi.org/10.1117/12.845782

KEYWORDS: Infrared cameras, Infrared imaging, Eye, Cameras, Image processing, Medical imaging, LCDs, Visual system, High dynamic range imaging, Medical imaging applications

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Showing 5 of 13 publications

Conference Committee Involvement (8)