Ms. Wei Yang Profile

Wei Yang

at Zhejiang Univ

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Proceedings Article | 8 March 2014 Paper

A novel phase-sensitive SPR biosensor array based on prism phase modulator

Gaoao Ye, Wei Yang, Li Jiang, Jun Qian, Sailing He

Proceedings Volume 8989, 89890Q (2014) https://doi.org/10.1117/12.2047367

KEYWORDS: Prisms, Biosensors, Microfluidics, Modulation, Surface plasmons, Sensors, Modulators, Refractive index, Gold, Fiber optics sensors

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Phase modulators in surface plasmon resonance phase-differential imaging (SPR-PI) sensing systems reported so far are sensitive to temperature fluctuations or mechanical vibrations and thus their applications are limited. In this paper, we propose a novel prism phase modulator (PPM) to replace a traditional modulator. The PPM consists of a parallel prism, a rotation stage and a mirror. The PPM shows great stability in our experiment, and helps achieve high detection sensitivity in our SPR-PI system. Moreover, the cost of our PPM is much lower than that of a traditional modulator and is thus suitable for commercialization. A polydimethylsiloxane (PDMS) microfluidic chip is fabricated to control the flow velocity and realize parallel detection in our experiment. Measured result of glycerine solution shows that the resolution of our SPR biosensor array is about 9.11×10^-7 refractive index unit (RIU). Real time monitoring of interaction between bovine IgG and anti-bovine IgG is also realized. The proposed PPM-based microfluidic SPR-PI biosensor array is promising for future practical applications.

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