Line-field confocal optical coherence tomography (LC-OCT) is an imaging technique based on time-domain OCT with line illumination and line detection. The focus is adjusted during the scan of the sample depth to image with high lateral resolution (~ 1 μm), similar to the axial resolution, at a central wavelength of ~ 800 nm. The LC-OCT prototypes reported so far were all based on a Linnik-type interferometer. We present in this paper a LC-OCT device based on a Mirau interferometer. This Mirau-based LC-OCT device has the advantage of being more compact and lighter. In vivo imaging of human skin with a resolution of 1.3 μm × 1.1 μm (lateral × axial) is demonstrated at 12 frames per second over a field of 0.9 mm × 0.4 mm (lateral × axial).
We present an improved time-domain optical coherence tomography technique designed for ultrahigh-resolution B-scan imaging in real-time. The technique, called line-field confocal optical coherence tomography, is based on a Linnik-type interference microscope with line illumination using a supercontinuum laser and line detection using a line-scan camera. Bscan imaging with dynamic focusing is achieved by acquiring multiple A-scans in parallel. In vivo cellular level resolution imaging of skin is demonstrated at 10 frame/s with a penetration depth of ∼ 500 μm, with a spatial resolution of 1.3 μm × 1.1 μm (transverse × axial).