Dr. Willy N. J. M. Colier Profile

Dr. Willy N. J. M. Colier

Physicist at Artinis Medical Systems BV

SPIE Involvement:

Conference Program Committee | Author

Proceedings Article | 6 March 2023 Presentation + Paper

A wearable optical sensor monitoring bladder urine volume to aid rehabilitation following spinal cord injury

A. Macnab, P. Pourabbassi, N. Hakimi, W. N. M. J. Colier, L. Stothers

Proceedings Volume 12375, 1237508 (2023) https://doi.org/10.1117/12.2650381

KEYWORDS: Bladder, Near infrared spectroscopy, Injuries, Transmitters, Signal attenuation, Spinal cord, Chromophores, Interfaces, Receivers, Optical sensing

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Proceedings Article | 6 March 2023 Presentation + Paper

Assessing stability and accuracy of a novel commercial wearable near-infrared spectroscopy device

Ivo da Mota Moreira, Thierry Willigenburg, Wout J. Kregting, Erwin R. Van Steijn, Marianne Floor-Westerdijk, Willy N. J. Colier

Proceedings Volume 12375, 123750A (2023) https://doi.org/10.1117/12.2657434

KEYWORDS: Sensors, Near infrared spectroscopy, Muscles, In vivo imaging, Education and training, Oxygenation, Tissues, Oxygen, Accuracy assessment, Reproducibility

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Proceedings Article | 6 March 2023 Presentation + Paper

Application of a recurrent neural network to predict the oxygenated recovery state following maximum isometric hand gripping exercise

B. Pol, T. Willigenburg, W. Kregting, S. Sappia, J. Horschig, W. Colier

Proceedings Volume 12375, 1237509 (2023) https://doi.org/10.1117/12.2653238

KEYWORDS: Muscles, Data modeling, Oxygenation, Near infrared spectroscopy, Neural networks, Statistical modeling, Performance modeling, Cross validation, Artificial intelligence, Machine learning

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Proceedings Article | 24 May 2022 Presentation + Paper

Clinical translation of optical quantification of muscle function to aid pelvic floor muscle rehabilitation following partial spinal cord injury

A. Macnab, N. Hakimi, W. N. J. Colier, M. Maresse, P. Pourabbassi, L. Stothers

Proceedings Volume 12146, 1214604 (2022) https://doi.org/10.1117/12.2624187

KEYWORDS: Near infrared spectroscopy, Oxygen, Injuries, Spinal cord, Interfaces, Receivers, Point-of-care devices, Chromophores, Visualization, Vagina

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Background: Spinal cord injury (SCI) compromises muscle function; when the pelvic floor muscles (PFM) are involved continence is affected. Women with partial injury rely on PFM rehabilitation therapy (PFMT) to aid continence, but the current lack of absolute measures to quantify training effects by monitoring changes in muscle oxygenation and perfusion hampers rehabilitation. We report clinical translation of a near infrared spectroscopic (NIRS) system to enable women with partial SCI to apply transvaginal optical detection of physiologic changes during PMFT as a point of care tool to quantify the effects of their PFM rehabilitation. Methods: The NIRS interface incorporates a circumferential grid of 6 LED emitters and 4 photodiode receivers with interoptode distances of 20 and 35 mm. The system was developed iteratively by engineers working with clinicians and patient care advocates to be clinically applicable for women following spinal cord injury. The continuous wave system uses 2-wavelengths (nominal 760nm, 850nm) and a sampling rate of 50Hz. Placed in the vagina during PMFT, the system monitors changes in oxy and deoxy-hemoglobin concentration (O₂Hb/HHb) in real time at multiple points in the PFM. The slope of reoxygenation recovery post contraction is a measure of muscle oxidative capacity. Results: A point of care system was successfully developed that provides a means of detecting chromophore change occurring in the PFM during muscular contraction. The chromophore changes monitored also allow an absolute measure, HbDiff half-recovery time (½RT) to be derived. Comparison of these data over time provides a means of evaluating PMFT regimens for a training effect. In preparation for application in subjects with SCI, the reproducibility of SMVCs was monitored successfully in a pilot study where a volunteer conducted a series of 4 SMVCs on 15 occasions. Discussion: Skeletal muscle recovery from exercise-induced oxygen deficit indicates oxidative capacity; this equates with muscular fitness. SMVC is a robust measure of muscle strength and endurance, and HbDiff in occlusion free ½RT analysis reflects metabolic changes within muscle better than O2Hb. This clinical translation of NIRS provides a hand held system for women to use to quantify physiologic changes in their PFM; this will aid women with partial spinal cord injury in whom PFM function may either be too weak to be detected by physical exam or manometry, and may only be present unilaterally. Hence the merit of an optical system able to provide quantifiable measures of reoxygenation recovery as a measure of PFM fitness. A quantitative physiologic measure for evaluating for PMFT training effect is currently lacking Conclusions: The collaborative development of this self-contained transvaginal NIRS system, and prior proof that optical detection of a validated quantifiable oxygenation parameter is feasible in the pelvic floor, now allows clinical evaluation using this point of care system to aid women with partial spinal cord injury. The aim is to enable them to use this system to optimize their PFM rehabilitation therapy as means of enhancing their continence and quality of life.

Proceedings Article | 5 March 2021 Presentation + Paper

Cerebral oxygenation responses to head movement measured with near-infrared spectroscopy

Iara de Almeida Ivo, Jörn Horschig, Svetlana Gerakaki, Marc van Wanrooij, Willy N. J. Colier

Proceedings Volume 11638, 116380G (2021) https://doi.org/10.1117/12.2587168

KEYWORDS: Head, Near infrared spectroscopy, Motion analysis, Neuroimaging

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Proceedings Article | 5 March 2021 Presentation + Paper

fNIRS signal quality estimation by means of a machine learning algorithm trained on morphological and temporal features

M. Sofía Sappia, Naser Hakimi, Liucija Svinkunaite, Thomas Alderliesten, Jörn Horschig, Willy N. J. Colier

Proceedings Volume 11638, 116380F (2021) https://doi.org/10.1117/12.2587188

KEYWORDS: Feature extraction, Machine learning, Signal analyzers, Algorithm development, Statistical analysis, Reliability, Hemodynamics, Functional near infrared spectroscopy, Binary data

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Proceedings Article | 11 April 2019 Paper

Functional near infrared spectroscopy (fNIRS) in pigmented subjects: a maneuver to confirm sufficient transcutaneous photon transmission for measurement of hemodynamic change in the anterior cortex

Mathijs Bronkhorst, Ronald Mukisa, Willy N. J. Colier, Lynn Stothers, Andrew Macnab

Proceedings Volume 11028, 1102813 (2019) https://doi.org/10.1117/12.2525240

KEYWORDS: Head, Skin, Near infrared spectroscopy, Hemodynamics, Sensors, Tissue optics, Absorption, Signal attenuation, Signal detection, Blood

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Proceedings Article | 15 October 2003 Paper

NIR spectroscopic measurement of local muscle metabolism during rhythmic, sustained, and intermittent handgrip exercise

Mireille van Beekvelt, Karin Orbon, Baziel van Engelen, Ron Wevers, Willy Colier

Proceedings Volume 5138, (2003) https://doi.org/10.1117/12.502380

KEYWORDS: Near infrared, Mode conditioning cables, Oxygen, Near infrared spectroscopy, Blood circulation, Tissues, Blood, Spectroscopy, Tissue optics, Blood vessels

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Proceedings Article | 29 July 2003 Paper

RSI: oxygen consumption, blood flow, and reoxygenation in patients suffering RSI measured by noninvasive optical spectroscopy

Dick Thijssen, Caro van Uden, Hans Krijgsman, Willy Colier

Proceedings Volume 4955, (2003) https://doi.org/10.1117/12.477355

KEYWORDS: Blood circulation, Adaptive optics, Oxygen, Injuries, Optical spectroscopy, Optical testing, Near infrared spectroscopy, Statistical analysis, Medicine, Infrared spectroscopy

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Proceedings Article | 29 June 2001 Paper

Real-time noninvasive optical imaging of exercising muscle and brain upon cognitive stimuli

Valentina Quaresima, Marco van der Sluijs, Jan Menssen, Lucia Grillotti, Marco Ferrari, Willy Colier

Proceedings Volume 4250, (2001) https://doi.org/10.1117/12.434514

KEYWORDS: Brain, Neuroimaging, Tissue optics, Near infrared, Blood circulation, Optical imaging, Oxygen, Near infrared spectroscopy, Spectroscopy, Mode conditioning cables

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Proceedings Article | 22 November 2000 Paper

Effect of subcutaneous arterial pulsation on determination of cerebral arterial oxygen saturation using NIRS

Ralph Houston, Jan Menssen, Marco van der Sluijs, Willy Colier, Berend Oeseburg

Proceedings Volume 4160, (2000) https://doi.org/10.1117/12.407611

KEYWORDS: Tissue optics, Arteries, Oxygen, Near infrared spectroscopy, Tissues, Signal detection, Transmitters, Receivers, Optical testing, Absorption

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Proceedings Article | 1 January 1998 Paper

Validation of measurement protocols to assess oxygen consumption and blood flow in the human forearm by near-infrared spectroscopy

Mireille Van Beekvelt, Willy Colier, Baziel van Engelen, Maria Hopman, Ron Wevers, Berend Oeseburg

Proceedings Volume 3194, (1998) https://doi.org/10.1117/12.301044

KEYWORDS: Near infrared spectroscopy, Blood circulation, Oxygen, Blood

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Proceedings Article | 1 January 1998 Paper

New and highly sensitive continuous-wave near-infrared spectrophotometer with multiple detectors

Marco van der Sluijs, Willy Colier, Ralph Houston, Berend Oeseburg

Proceedings Volume 3194, (1998) https://doi.org/10.1117/12.301097

KEYWORDS: Continuous wave operation, Spectrophotometry, Sensors, Near infrared, Tissues, Temporal resolution, Signal to noise ratio, Brain imaging, Laser development, Absorbance

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Proceedings Article | 18 August 1997 Paper

Detailed evidence of cerebral hemoglobin oxygenation changes in response to motor cortical activation revealed by a continuous-wave spectrophotometer with 10-Hz temporal resolution

Willy Colier, Valentina Quaresima, Giovanna Baratelli, Paolo Cavallari, Marco van der Sluijs, Marco Ferrari

Proceedings Volume 2979, (1997) https://doi.org/10.1117/12.280269

KEYWORDS: Near infrared spectroscopy, Temporal resolution, Heart, Cortical activation, Spectrophotometry, Electronic filtering, Physiology, Resolution enhancement technologies, Absorbance, Continuous wave operation

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SPIE Journal Paper | 2 April 1997 Open Access

Age dependency of cerebral oxygenation assessed with near infrared spectroscopy

Willy Colier, Nicole van Haaren, Marjo van de Ven, Hans Folgering, Berend Oeseburg

JBO, Vol. 2, Issue 02, (April 1997) https://doi.org/10.1117/12.10.1117/12.269891

KEYWORDS: Near infrared spectroscopy, Oxygen, Blood, Carbon monoxide, Tissue optics, Brain, Hemodynamics, Oximeters, Cerebral blood flow, Statistical analysis

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Showing 5 of 15 publications

Conference Committee Involvement (6)

Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables V

27 January 2024 | San Francisco, California, United States

Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables IV

28 January 2023 | San Francisco, California, United States

Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables III

22 January 2022 | San Francisco, California, United States

Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables II

6 March 2021 | Online Only, California, United States

Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables

1 February 2020 | San Francisco, California, United States

Showing 5 of 6 Conference Committees

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