In recent years, hazmat transportation’s accidents occur frequently and the road safety transportation issues become increasingly prominent with the demanding for road transport of hazardous goods. However, there are too many types of hazardous goods and every single type has one or several characters. Some of the parameters which are related to security need to be monitored when it comes to transportation. For the tough problem above, this paper presents a sensor data collection technical scheme that is based on the RS485 bus technology. Sensor modules are distributed at various parts of the lorry in order to measure the critical state information of the transporting goods. More importantly, users can get various critical state information they want which corresponds with the transported hazmat by putting different types of sensor modules onto RS485 bus. Combine the above technical scheme with GPS technology and CDMA radio transmission technology, the key state information and location information of the hazmat can be transferred to the supervision and management center to meet the demand of state monitoring.