Ms. Xianglian Liao Profile

Xianglian Liao

at Fujian Normal Univ.

SPIE Involvement:

Author

Publications (2)

This will count as one of your downloads.

You will have access to both the presentation and article (if available).

DOWNLOAD NOW

This content is available for download via your institution's subscription. To access this item, please sign in to your personal account.

Email or Username Forgot your username?

Password Forgot your password?

Show

Keep me signed in

No SPIE account? Create an account

Proceedings Article | 20 November 2019 Paper

Detection of singlet oxygen luminescence in skin phantom based on optical fiber detection

Ying Hu, Lisheng Lin, Lina Liu, Yunfei Yu, Xianglian Liao, Ying Gu, Buhong Li

Proceedings Volume 11190, 111902X (2019) https://doi.org/10.1117/12.2537692

KEYWORDS: Luminescence, Oxygen, Scattering, Optical fibers, Skin, Absorption, Photodynamic therapy, Tissue optics, Light scattering, Sensors

Read Abstract +

Singlet oxygen (¹O₂) is widely considered as the major cytotoxic species generated during Type-II photochemical reaction of photodynamic therapy (PDT), and its production is crucial for the treatment outcome of PDT. However, it is still a challenging task for direct detection of ¹O₂ by using an optical system as its extremely weak luminescence at 1270 nm. In previous study, a high-sensitivity optical fiber detection system has been developed to measure the time-resolved ¹O₂ luminescence spectra. In this study, an optical phantom of skin tissue has been built to simulate the skin optical properties for research in photodynamic therapy (PDT). The phantom consists of an absorber (ink) and a scatterer (Intralipid) and phosphate buffer saline (PBS). Rose Bengal (RB) was utilized as the model photosensitizer to generate ¹O₂. The time-resolved ¹O₂ luminescence spectroscopy were measured by using a ¹O₂ luminescence detection system with a fiber prober in tissue phantom. Furthermore, the effect of absorption coefficient (μ_a) and scattering coefficient (μ_s) on the photosensitizer triple state lifetime (τ_T) and ¹O₂ luminescence lifetime (τ_D) was investigated as well. The results indicated that the integrated intensity of ¹O₂ luminescence decrease with the increase of μ_a and μ_s. μ_a has no significant effect on τ_T and τ_D. τ_T increase with the increase of μ_s, and it finally stabilized around 1.6 μs. Meanwhile, τ_D decrease firstly and then increase slowly, and it finally stabilized around 14 μs. This result indicates that this system for ¹O₂ luminescence have a potential for clinical applications in PDT dosimetry.

Proceedings Article | 23 October 2018 Paper

Impacts of vascular diameter and depth on singlet oxygen luminescence imaging in tissue simulating phantom

Xianglian Liao, Yi Shen, Yunfei Yu, Huiyun Lin, Lisheng Lin, Ying Gu, Buhong Li

Proceedings Volume 10820, 108203I (2018) https://doi.org/10.1117/12.2502717

KEYWORDS: Luminescence, Capillaries, Tissues, Photodynamic therapy, Blood vessels, Imaging systems

Read Abstract +

Singlet oxygen (¹O₂) is the primary cytotoxic production in type-II photodynamic therapy (PDT). The correlation between ¹O₂ generation and PDT efficacy during treatment has received considerable attention. The direct detection of ¹O₂ luminescence is the gold standard for ¹O₂ identification. However, the intensity of ¹O₂ luminescence could be influenced by tissue optical properties, location and morphology of lesion, especially for vascular targeting PDT. In this study, the impacts of vascular diameter and depth on ¹O₂ luminescence imaging have been investigated in tissue simulating phantom. A near-IR sensitive InGaAs camera with adaptive optics and CW laser 532 nm were used for fast imaging of ¹O₂ luminescence. Rose Bengal (RB) was used as photosensitizer to generate ¹O₂ during photosensitization. Intralipid was diluted with different concentrations in order to establish the scattering properties of tissues. The capillary tubes, containing solution of RB, with varied diameters from 0.1 to 0.9 mm were used to simulate the vascular with the depth varied from 0 to 5 mm in phantom. The preliminary results indicate that the profile range ratio of ¹O₂ luminescence images are negatively correlated to the diameter of capillary tube, and the attenuation of intensity of ¹O₂ luminescence is non-linear with the increase of depth.

My Library

You currently do not have any folders to save your paper to! Create a new folder below.

Folder Name

Folder Description

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks. You are receiving this notice because your organization may not have SPIE eBooks access.*

*Shibboleth/Open Athens users─please sign in to access your institution's subscriptions.

To obtain this item, you may purchase the complete book in print or electronic format on SPIE.org.

ORGANIZATIONAL
Sign in with credentials provided by your organization.

Organizational Username

Organizational Password

Show/Hide Password

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members:

Non-members: ADD TO CART

Keywords/Phrases

Search In:

Publication Years