Mr. Xiaodong Zhou Profile

Xiaodong Zhou

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Publications (11)

Proceedings Article | 19 February 2008 Paper

Integrated light dosimetry system for prostate photodynamic therapy

Jun Li, Timothy Zhu, Xiaodong Zhou, Dimofte Andreea, Jarod Finlay

Proceedings Volume 6845, 68450Q (2008) https://doi.org/10.1117/12.763806

KEYWORDS: Prostate, Light, Photodynamic therapy, Optical properties, Optical testing, Optimization (mathematics), Finite element methods, Light sources, In vivo imaging, Attenuators

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Proceedings Article | 18 February 2008 Paper

Sensitivity analysis of imaging geometries for prostate diffuse optical tomography

Xiaodong Zhou, Timothy Zhu

Proceedings Volume 6845, 68450P (2008) https://doi.org/10.1117/12.764222

KEYWORDS: Endoscopy, Sensors, Prostate, Tissues, Diffuse optical tomography, Optical properties, Diffuse optical imaging, 3D metrology, Photodynamic therapy, Data acquisition

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Proceedings Article | 11 February 2008 Paper

Interstitial diffuse optical tomography using an adjoint model with linear sources

Xiaodong Zhou, Timothy Zhu

Proceedings Volume 6845, 68450C (2008) https://doi.org/10.1117/12.762340

KEYWORDS: Optical properties, Sensors, Prostate, Absorption, Reconstruction algorithms, Photodynamic therapy, Data acquisition, 3D modeling, Data modeling, Scattering

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Proceedings Article | 6 March 2007 Paper

Macroscopic modeling of the singlet oxygen production during PDT

Timothy Zhu, Jarod Finlay, Xiaodong Zhou, Jun Li

Proceedings Volume 6427, 642708 (2007) https://doi.org/10.1117/12.701387

KEYWORDS: Oxygen, Photodynamic therapy, Tissues, Tissue optics, Capillaries, Diffusion, Blood circulation, Tumors, Quantum efficiency, Blood vessels

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Proceedings Article | 27 February 2007 Paper

Tumor vascular volume determines photosensitizer uptake in MATLyLu prostate tumor model

Xiaodong Zhou, Bin Chen, P. Jack Hoopes, Tayyaba Hasan, Brian Pogue

Proceedings Volume 6427, 64270S (2007) https://doi.org/10.1117/12.699033

KEYWORDS: Tumors, Luminescence, Diffusion, Molecules, Cancer, Data modeling, Photodynamic therapy, Tissues, Plasma, Prostate

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Proceedings Article | 27 February 2007 Paper

A method to improve reconstruction of the distribution of hemoglobin, oxygenation, and MLu concentration in the human prostate before and after photodynamic therapy

Jarod Finlay, Timothy Zhu, Xiaodong Zhou, Andreea Dimofte, S. Malkowicz, Stephen Hahn

Proceedings Volume 6427, 64270K (2007) https://doi.org/10.1117/12.699545

KEYWORDS: Absorption, Prostate, Scattering, Photodynamic therapy, Spectroscopy, Optical properties, Sensors, Reconstruction algorithms, Tissue optics, Tissues

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Proceedings Article | 14 February 2007 Paper

Two-dimensional/three-dimensional hybrid interstitial diffuse optical tomography of human prostate during photodynamic therapy: phantom and clinical results

Xiaodong Zhou, Timothy Zhu, Jarod Finlay, Jun Li, Andreea Dimofte, Stephen Hahn

Proceedings Volume 6434, 64341Y (2007) https://doi.org/10.1117/12.701717

KEYWORDS: Prostate, Reconstruction algorithms, Optical properties, 3D modeling, Sensors, Photodynamic therapy, Absorption, Diffuse optical tomography, Scattering, Tissue optics

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Proceedings Article | 6 March 2006 Paper

Photosensitizer dosimetry controlled PDT treatment planning reduces inter-individual variability in response to PDT

Xiaodong Zhou, Brian Pogue, Bin Chen, Eugene Demidenko, Rohan Joshi, Jack Hoopes, Tayyaba Hasan

Proceedings Volume 6139, 61390P (2006) https://doi.org/10.1117/12.647439

KEYWORDS: Tumors, Photodynamic therapy, Picosecond phenomena, Luminescence, Tissue optics, Animal model studies, Tissues, Oxygen, Prostate, In vivo imaging

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Effective Photodynamic therapy (PDT) treatment depends on the amount of active photosensitizer and the delivered light in the targeting tissue. For the same PDT treatment protocol, variation in photosensitizer uptake between animals induces variation in the treatment response between animals. This variation can be compensated via control of delivered light dose through photodynamic dose escalation based on online dosimetry of photosensitizer in the animal. The subcutaneous MAT-LyLu Dunning prostate tumor model was used in this study. Photosensitizer BPD-MA uptake was quantified by multiple fluorescence micro-probe measurements at 3 hours after verteporfin administration. PDT irradiation was carried out after photosensitizer uptake measurement with a total light dose of 75 J/cm2 and a light dose rate of 50 mW/cm2. Therapeutic response of PDT treatments was evaluated by the tumor regrowth assay. Verteporfin uptake varied considerably among tumors (inter-tumor variation 56% standard deviation) and within a tumor (largest intra-tumor variation 64%). An inverse correlation was found between mean photosensitizer intensity and PDT treatment effectiveness (R2 = 37.3%, p < 0.005). In order to compensate individual PDT treatments, photodynamic doses were calculated on an individual animal basis, by matching the light delivered to provide an equal photosensitizer dose multiplied by light dose. This was completed for the lower-quartile, mean and upper-quartile of the photosensitizer distribution. The coefficient of variance in the surviving fraction decreased from 24.9% in non-compensated PDT (NC-PDT) treatments to 16.0%, 14.0% and 15.9% in groups compensated to the lower-quartile (CL-PDT), the median (CM-PDT) and the upper-quartile (CU-PDT), respectively. In terms of treatment efficacy, the CL-PDT group was significantly less effective compared with NC-PDT, CM-PDT and CU-PDT treatments (p < 0.005). No significant difference in effectiveness was observed between NC-PDT, CM-PDT and CU-PDT. The results indicate that by measuring the mean photosensitizer concentration prior to light treatment, and then adjusting the light dose appropriately, a more uniform treatment can be applied to different animals thereby reducing the inter-individual variation in the treatment outcome.

Proceedings Article | 6 March 2006 Paper

Comparison of techniques for quantification of fluorescence from tissue

Brian Pogue, Xiaodong Zhou, Summer Gibbs, Scott Davis, Dax Kepshire, Keith Paulsen, Tayyaba Hasan

Proceedings Volume 6139, 61390N (2006) https://doi.org/10.1117/12.647572

KEYWORDS: Luminescence, Tissues, In vivo imaging, Tissue optics, Tumors, Imaging systems, Tomography, Raster graphics, Scattering, Confocal microscopy

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SPIE Journal Paper | 1 July 2005 Open Access

Analysis of sampling volume and tissue heterogeneity on the in vivo detection of fluorescence

Brian Pogue, Bin Chen, Xiaodong Zhou, P. Jack Hoopes

JBO, Vol. 10, Issue 04, 041206, (July 2005) https://doi.org/10.1117/12.10.1117/1.2002978

KEYWORDS: Luminescence, Tumors, Tissues, In vivo imaging, Tissue optics, Microscopy, Statistical analysis, Signal detection, Biological research, Fluorescence spectroscopy

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Proceedings Article | 13 June 2003 Paper

Light dosimetry for photodynamic therapy in the esophagus

Xiaodong Zhou, Brian Pogue, Norman Nishioka, Bill Puricelli, Tayyaba Hasan

Proceedings Volume 4952, (2003) https://doi.org/10.1117/12.474083

KEYWORDS: Esophagus, Diffusers, Monte Carlo methods, Tissue optics, Photodynamic therapy, Scattering, Absorption, Light scattering, Optical properties, Mathematical modeling

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Showing 5 of 11 publications

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