Dr. Xiaoying Tian Profile

Dr. Xiaoying Tian

at Shanghai Jiao Tong Univ

SPIE Involvement:

Author

Publications (1)

This will count as one of your downloads.

You will have access to both the presentation and article (if available).

DOWNLOAD NOW

This content is available for download via your institution's subscription. To access this item, please sign in to your personal account.

Email or Username Forgot your username?

Password Forgot your password?

Show

Keep me signed in

No SPIE account? Create an account

Proceedings Article | 20 November 2019 Paper

Ultrahigh-resolution stimulation by femtosecond laser reveals existence and regulation mechanism of nuclear Ca2+ store

Xiaoying Tian, Hao He

Proc. SPIE. 11190, Optics in Health Care and Biomedical Optics IX

KEYWORDS: Femtosecond phenomena, Photostimulation, Calcium, Detection theory, Cell mechanics

Read Abstract +

Nuclear Ca²⁺ regulates many signaling pathways including NFAT, CREB, MEF that are essential to cell immunity, development and differentiation. In current stage, there is no specified biochemical drugs to regulate nuclear Ca²⁺ individually. The existence of nuclear Ca²⁺ store remains unknown. In this study, we show the femtosecond-laser stimulation can precisely regulate nuclear and other subcellular Ca²⁺ stores exclusively. The stimulated Ca²⁺ store can be released but other subcellular Ca²⁺ stores are not interfered by femtosecond laser. By using this method, we present the evidence of the endogenous Ca²⁺ store inside nucleus. The nuclear Ca²⁺ store volume and release mechanism are clarified. By photostimulation, nuclear Ca²⁺ store can be released and impact the calcium in endoplasmic reticulum (ER), suggesting a Ca²⁺ transmission channel between nucleus and ER. The permeability of nuclear pore complex (NPC) to Ca²⁺ at different Ca²⁺ levels is also found different. This study indicates the existence of nuclear Ca²⁺ store and the final mapping of subcellular Ca²⁺ stores. This result thus is of great significance to the cell calcium theory, Ca²⁺ signaling, Ca²⁺-related cell processes, and further other Ca²⁺-related fields.

My Library

You currently do not have any folders to save your paper to! Create a new folder below.

Folder Name

Folder Description

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks. You are receiving this notice because your organization may not have SPIE eBooks access.*

*Shibboleth/Open Athens users─please sign in to access your institution's subscriptions.

To obtain this item, you may purchase the complete book in print format on SPIE.org.

PERSONAL SIGN IN
Full access may be available with your subscription

Email or Username Forgot your username?

Password Forgot your password?

Show

Keep me signed in

No SPIE account? Create an account

Institutional Access:

PURCHASE THIS CONTENT

INTERESTED IN A FREE CORPORATE TRIAL?

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members:

Non-members: ADD TO CART

Keywords/Phrases

Search In:

Publication Years