The accuracy and reproducibility of hemodynamic simulation for a brain aneurysm system was determined by comparison of physical measurements made in a curved duct with the corresponding simulations produced by three different solvers, and by inter-solver comparison of blood flow in a patient-specific, imaging-based model of an aneurysm. The simulations were in close agreement with measurements made in the square duct. This suggests that hemodynamic simulation is accurate for models with strong curvature flow. The simulation results produced by solvers using the model of the brain aneurysm were consistent with each other, suggesting that hemodynamic simulations of patient-specific imaging-based aneurysm models are consistent and reproducible by different solvers. These results support the validity of patient-specific imaging-based simulations.