A novel polymeric nanoparticle was developed between the negatively charged dendrimer phthalocyanine and positively triblock copolymer for the use as an effective photosensitizer in photodynamic therapy. The intracellular uptake of dendrimer phthalocyanines in HeLa cell was significantly enhanced by encapsulated into nanoparticles. The photocytotoxicity of dendrimer phthalocyanines incorporated into polymeric micelles was also increased. The presence of nanoparticles located induced efficient cell death.
As an excellent second-generation photosensitizer for photodynamic therapy (PDT), phthalocyanine (Pc) complex has strong absorption peak in the near-infrared region and strong tissue penetrating ability, which endowed them excellent properties for the detection of tumor tissue. In recent years, in order to further ehnaced the penetration depth of the photosensitizer to the tissue, a large number of functional groups have been synthesized . In this work, we designed and synthesized metronidazole-substituted dendrimer silicon phthalocyanine (MT-SiPc) with near-infrared region Q-band of UV absorption, excellent fluorescence properties and photochemical properties.