Xuhui Liu
at Univ of Kentucky
SPIE Involvement:
Area of Expertise:
Cerebral Hemodynamics Monitoring , Noninvasive Wearable Device , Near-infrared spectroscopy , Diffuse Optical Spectroscopy , Laser Speckle Contrast Imaging , 3D Printing
Profile Summary

I am a Ph.D. candidate in the Department of Biomedical Engineering at the University of Kentucky. My research focuses on the development of diffuse optical spectroscopic and tomographic wearable technologies for the noninvasive assessment of tissue hemodynamics and metabolism. I am currently working on the development of a low-cost, wearable, wireless, and non-invasive optical sensor for cerebral hemodynamics and metabolism monitoring in freely moving subjects. My research project has generated several publications and has been awarded by Halcomb Fellowship in Medicine and Engineering ($30,000; 2021-2022). My professional/project experience is in the following area:

1. Wearable Device Prototyping:
a. Developed a near-infrared tissue oximeter using NI DAQ board, LEDs, photodiode.
b. Developed a wearable optical sensor for cerebral blood flow and oxygenation monitoring using Arduino Uno, laser diodes, and camera.
c. Developing a wireless wearable sensor for continuous cerebral monitoring using Raspberry Pi and Bluetooth.

2. 3D Printing
a. Designed and printed animal constraint frame for piglet brain MRI scanning using a conventional 3D printer.
b. Designed a wearable head-stage/probe for rodents’ cerebral monitoring using an SLA 3D printer.
c. Designed a wearable band to fix the cerebral monitoring sensor on the infant’s head using a skin-safe flexible filament.

3. Image Data Analysis:
a. Extract the longitudinal blood flow information from a time series of raw speckle images.
b. Extract blood oxygenation information from raw intensity images using modified Beer-Lambart law.
c. Laser speckle contrast imaging analysis.

4. Optical System Testing/calibration:
a. Test and calibrate an optical system with a high-power near-infrared laser and a CMOS camera for tissue hemodynamics monitoring.

Publications (8)

Proceedings Article | 13 March 2024 Presentation
Fatemeh Hamedi, Chong Huang, Faezeh Akbari, Xuhui Liu, Mehrana Mohtasebi, Chaebeom Yeo, Lei Chen, Guoqiang Yu
Proceedings Volume PC12827, PC128270E (2024) https://doi.org/10.1117/12.3001780
KEYWORDS: Miniaturization, Tomography, Speckle, Cerebral blood flow, Portability, Brain, Neuroimaging, Equipment, Cameras, Brain mapping

SPIE Journal Paper | 14 November 2023 Open Access
NPh, Vol. 10, Issue 04, 045007, (November 2023) https://doi.org/10.1117/12.10.1117/1.NPh.10.4.045007
KEYWORDS: Speckle, Laser speckle contrast imaging, Windows, Brain mapping, Simulation of CCA and DLA aggregates, Brain, 3D modeling, Spatial resolution, Tissues, Neurophotonics

SPIE Journal Paper | 4 May 2023 Open Access
JBO, Vol. 28, Issue 12, 121204, (May 2023) https://doi.org/10.1117/12.10.1117/1.JBO.28.12.121204
KEYWORDS: Brain, Ischemia, Simulation of CCA and DLA aggregates, Windows, Speckle, 3D image reconstruction, Sampling rates, Tissues, Reconstruction algorithms, Neuroimaging

Proceedings Article | 7 March 2022 Presentation
Proceedings Volume PC11944, PC119440G (2022) https://doi.org/10.1117/12.2610178
KEYWORDS: Laser speckle contrast imaging, Pulsed laser operation, Picosecond phenomena, Imaging systems, Cerebral blood flow, Continuous wave operation, Diffusers, System integration, Laser crystals, Glasses

Proceedings Article | 7 March 2022 Presentation
Proceedings Volume PC11945, PC1194505 (2022) https://doi.org/10.1117/12.2609144
KEYWORDS: Ischemic stroke, Brain, Tissue optics, Stereoscopy, Traumatic brain injury, Tomography, Tissues, Speckle, Signal attenuation, Safety

Showing 5 of 8 publications
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