In a preclinical study, we demonstrated that blood flow and tissue oxygenation could be manipulated
by focused ultrasound; the effects of such manipulation were interrogated via optical spectroscopy at
wavelengths where oxy- and deoxy-hemoglobin display different extinction properties. We have
designed a clinical breast scanner based on these noninvasive techniques. In addition to the focused
ultrasound field intersecting with the volume of optical illumination and points of spectral collection,
a diagnostic quality breast imaging probe is incorporated into the scanhead to achieve image
guidance. Experimental confirmation of the system performance of the focused ultrasound field
properties, diagnostic imaging capabilities and NIR spectroscopy subsystem has been carried out to
demonstrate readiness for a clinical study involving 200 patients who are scheduled to undergo
ultrasound-guided biopsy to rule out breast cancers.
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