This paper analyzes the performance of a fast, low complexity, integer-to-integer compression scheme that is designed to give greater importance to small targets. Practical real-time operation of unmanned aerial vehicle mine/minefield detection systems has two difficult constraints. One is limited data-link bandwidth and the other is limited on-board processing power. Standard compression techniques are usually complex and tend to remove small objects from the imagery. In the imagery used for airborne mine/minefield detection, the targets are small, usually on the order of a few pixels. The region-of-interest (ROI) Wavelet Difference Reduction (WDR) compression scheme satisfies both of these con-straints and is shown to preserve detection rates of small targets. Results are compared for block-based (BB)-WDR compressed and ROI-WDR compressed and uncompressed images. The ROI -WDR process is shown to be superior to other compression conditions.