Optical coherence tomography(OCT) is a high resolution imaging technique which uses light to directly image living
tissue. we investigate the potential use of OCT for structural imaging of the ischemia injury mammalian cerebral cortex.
And we examine models of middle cerebral artery occlusion (MCAO) in rats in vivo using OCT. In particular, we show
that OCT can perform in vivo detection of cortex and differentiate normal and abnormal cortical anatomy. This OCT
system in this study provided an axial resolution of 10~15μ m, the transverse resolution of the system is about 25 μm.
OCT can provide cross-sectional images of cortical of adult rats in response to cerebral ischemia injury.We conclude that
OCT represents an exciting new approach to visualize, in real-time, pathological changes in the cerebral cortex structures
and may offer a new tool for Possible neuroscience clinical applications.