PROCEEDINGS ARTICLE | May 1, 2007
Proc. SPIE. 6534, Fifth International Conference on Photonics and Imaging in Biology and Medicine
KEYWORDS: Photodetectors, Mirrors, Particles, Biosensors, Control systems, Phosphorescence, LCDs, Data processing, Particle filters, Process control
A new generation of Up-converting phosphor technology-based biosensors (UPT-based biosensor) has been developed
for immunoassay, where a kind of novel Up-converting phosphor (UCP) particle serves as the biological marker. Its
control system is based on a micro-computer control unit instead of a personal computer, which results in low power
consumption, high reliability and portability for field detection. By detecting the content of the UCP on the test strip, the
system figures out the concentration of the biological molecular of interest, which can be used in field examination of
biological analytes. In this paper, a series concentration of standard samples have been tested by the biosensor, which is
proved to have higher sensitivity (~ng/ml), higher stability (CV<3~5%), better linear relationship and an excellent
correlation (R2≥0.95). The UPT-based biosensor has stable, reliable and sensitive performances. It can meet the need of
various rapid bioassay applications.
