A noninvasive glucose monitoring system based on mid-infrared, attenuated total reflection spectroscopy using a hollow optical fiber probe is developed. Owing to the flexible fiber probe, measurement of oral mucosa, where blood capillaries are near the skin surface, is possible. Blood glucose levels are measured by detecting the peak intensity of glucose absorption bands, and the experimental results showed that the reproducibility of the measurement is high enough for monitoring blood glucose.
An infrared spectroscopy system based on a hollow-optical fiber probe for measurement of blood glucose concentration is developed. The probe consists of a flexible hollow-optical fiber and an ATR prism attached at the distal end of the fiber. This flexible probe enables measurement of oral mucosa and ear lobes that have blood capillaries near the skin surface. Experimental results show that absorption peaks of blood glucose are detected by the system.