In this work, a nanoscale surface-enhanced Raman scattering (SERS) substrate is fabricated by fs laser reduction and
deposition. The conductive silver microstructures are also deposited in fs laser irradiated area on the glass surfaces.
Based on this approach, we integrate the microelectronic circuit and micro-Raman substrate into a microfluidic chamber
and form a prototype of Raman biochip for biosensing. Enhancement of Raman signal and control of temperature of the
sensor are both achieved. This technique provides a great potential for integrating microelectronics and micro-Raman
sensors on a single glass chip.
In this paper, selective deposition of conductive copper films on glass surfaces is demonstrated with the assistance of
femtosecond laser surface modification followed by electroless plating. Irradiation of femtosecond laser makes it
possible to selectively deposit copper films in the irradiated area on glass surfaces coated with silver nitrate films. The
influence of the laser direct writing parameters and the electroless plating process on the formation of copper films is
discussed. Meanwhile, the electric properties of copper films are investigated, which confirms that copper films are
conductive. A tentative mechanism of the selective deposition process is also proposed. In addition, the potential
application of this technique for integrating electrical and thermal functions into microdevices is discussed.
We report the fabrication of novel surface-enhanced Raman scattering (SERS) substrate and microfluidic
optical waveguide using fs laser direct writing, which are crucial elements on biophotonic biochips.
The combination of the confocal scanning microscopy and the defocusing imaging in the plane of imaging system was proposed. A switch lens and a pinhole with fine focusing aid are used to switch between the confocal scanning imaging mode and defocusing imaging mode. Objectives of different magnification can be used to get different field of vision. The complementary images can offer more information than any single one. Image blur or distortion caused by scanning, such as the displacement of the target and the excursion of scanning stage, can be corrected according to the comparison of two images. Location and adjustment of the target can be achieved easily and the accuracy of scanning image will be improved obviously. Some samples were tested on a home-built system.