Cholesterol plays a very important role in human physiological function, and the level of cholesterol in human body is a marker for diagnosing a variety of diseases. The article proposes a localized surface plasmon resonance (LSPR) sensor based on dual-tapered optical fiber (DTOF) that can detect cholesterol concentrations in the human body. To excite the LSPR effect and improve the sensing probe's sensitivity, gold nanoparticles (AuNPs) were immobilized on the surface of the DTOF. In this work, the specific reaction between cholesterol and cholesterol oxidase led to the change of refractive index (RI) near the sensing probe, and the corresponding spectrum is collected. Additionally, the performance of the sensor was evaluated, including linear range, reproducibility, reusability, stability, and selectivity. The experimental results demonstrate that the proposed DTOF-based LSPR sensor is capable of detecting the cholesterol level accurately and has a promising application in biomedicine.
In this work, a simple and effective sensor using single-mode fiber (SMF) tapered structure is developed to detect different concentrations of acetylcholine solutions, and its function is to test the probe's performance. A layer of synthesized gold nanoparticles (AuNPs) and zinc oxide nanoparticles (ZnO-NPs) is used to immobilize this type of SMF-based tapered structure. The work is based on the well-known phenomenon of localized surface plasmon resonance (LSPR) principle. A tapered region of the probe with a high fraction power of evanescent wave can stimulate LSPR and produce specific absorption peaks sensitive to the refractive index variation. The sensor probes performance was examined, including their stability, repeatability, reusability, and selectivity. Furthermore, the biosensor's ability to improve performance was tested in the experiment.
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