Prof. Zhihong Zhang Profile

Prof. Zhihong Zhang

Professor at Huazhong Univ of Science and Technology

SPIE Involvement:

Conference Program Committee | Author

Publications (49)

PROCEEDINGS ARTICLE | April 19, 2017

Dynamical optical imaging monocytes/macrophages migration and activation in contact hypersensitivity (Conference Presentation)

Proc. SPIE. 10065, Biophotonics and Immune Responses XII

KEYWORDS: Optical imaging, Biomedical optics, Blood, Skin, Microscopy, Inflammation, Molecular imaging, In vivo imaging, Fluorescent proteins, Mouse models

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PROCEEDINGS ARTICLE | April 19, 2017

A lipid-based nano-regulator for cancer immunotherapy (Conference Presentation)

Proc. SPIE. 10065, Biophotonics and Immune Responses XII

KEYWORDS: Nanotechnology, Biomedical optics, Cancer, Tumors, Nanoparticles, Molecules, Lymphatic system, Current controlled current source

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PROCEEDINGS ARTICLE | March 15, 2016

CT/FMT dual-model imaging of breast cancer based on peptide-lipid nanoparticles

Proc. SPIE. 9709, Biophotonics and Immune Responses XI

KEYWORDS: Breast, 3D acquisition, X-ray computed tomography, Cancer, Breast cancer, Tumors, Tissues, Nanoparticles, Luminescence, Tomography, Mammography, In vivo imaging, In vitro testing, Fluorescence tomography

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PROCEEDINGS ARTICLE | March 15, 2016

Dynamic visualization the whole process of cytotoxic T lymphocytes killing the B16 tumor cells in vitro

Proc. SPIE. 9709, Biophotonics and Immune Responses XI

KEYWORDS: Confocal microscopy, Biomedical optics, Statistical analysis, Cancer, Tumors, Visualization, Imaging systems, Flow cytometry, Signal detection, In vitro testing

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PROCEEDINGS ARTICLE | March 9, 2015

Tumor redox metabolism correlation with the expression level of red fluorescent protein

Proc. SPIE. 9324, Biophotonics and Immune Responses X

KEYWORDS: Proteins, Tumor growth modeling, Cancer, Tumors, Tissues, Scanners, Luminescence, Melanoma, Fluorescent proteins, Mode conditioning cables

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PROCEEDINGS ARTICLE | March 9, 2015

Intravital imaging of multicolor-labeled tumor immune microenvironment through skin-fold window chamber

Proc. SPIE. 9324, Biophotonics and Immune Responses X

KEYWORDS: Biomedical optics, Tumors, Video, Microscopy, Photonics, In vivo imaging, Fluorescent proteins, Signal detection, 3D image processing, Data analysis

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PROCEEDINGS ARTICLE | March 5, 2014

Impact of rapamycin on phenotype and tolerogenic function of dendritic cells via intravital optical imaging

Proc. SPIE. 8944, Biophotonics and Immune Responses IX

KEYWORDS: Optical imaging, Confocal microscopy, Statistical analysis, Tissues, Molecules, Transplantation, Bone, Tolerancing, In vitro testing, Lymphatic system

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PROCEEDINGS ARTICLE | February 27, 2014

Metabolic imaging of the tumor treated by KillerRed fluorescent protein-based photodynamic therapy in mice

Proc. SPIE. 8944, Biophotonics and Immune Responses IX

KEYWORDS: Proteins, Photodynamic therapy, Biomedical optics, Tumors, Luminescence, Oxygen, In vivo imaging, Fluorescent proteins, Flavoproteins, Mode conditioning cables

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SPIE Journal Paper | January 27, 2014

Preclinical evidence of mitochondrial nicotinamide adenine dinucleotide as an effective alarm parameter under hypoxia

Shi, Hua , Sun, Nannan , Mayevsky, Avraham , Zhang, Zhihong , Luo, Qingming

JBO Vol. 19 Issue 01

KEYWORDS: Hypoxia, Electrocardiography, Reflectivity, Oxygen, Tissues, Luminescence, Brain, Cerebral blood flow, Arteries, Nitrogen

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SPIE Journal Paper | July 9, 2012

Real-time imaging elucidates the role of H2O2 in regulating kinetics of epidermal growth factor-induced and Src-mediated tyrosine phosphorylation signaling

Su, Ting , Li, Xiangyong , Liu, Nisha , Pan, Shaotao , Lu, Jinling , Yang, Jie , Zhang, Zhihong

JBO Vol. 17 Issue 7

KEYWORDS: Biosensors, Proteins, Control systems, Real time imaging, Modulation, Signal attenuation, Fluorescence resonance energy transfer, Fluorescent proteins, Image processing, Oxidation

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SPIE Journal Paper | June 5, 2012

Monitoring the process of pulmonary melanoma metastasis using large area and label-free nonlinear optical microscopy

Hua, Daozhu , Qi, Shuhong , Li, Hui , Zhang, Zhihong , Fu, Ling

JBO Vol. 17 Issue 06

KEYWORDS: Tissues, Second-harmonic generation, Melanoma, Cancer, Lung, Collagen, Nano opto mechanical systems, Microscopy, Optical microscopy, Tumors

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PROCEEDINGS ARTICLE | March 6, 2009

Five-color fluorescent imaging in living tumor cells

Proc. SPIE. 7280, Seventh International Conference on Photonics and Imaging in Biology and Medicine

KEYWORDS: Confocal microscopy, Proteins, Tumors, Glasses, Imaging technologies, Luminescence, Photonics, Fluorescent proteins, Plasma, Bandpass filters

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PROCEEDINGS ARTICLE | February 25, 2009

Real-time optical imaging of the interaction of epidermal growth factor and its receptor in living cells

Proc. SPIE. 7178, Biophotonics and Immune Responses IV

KEYWORDS: Optical imaging, Proteins, Green fluorescent protein, Cancer, Visualization, Molecules, Receptors, Fluorescence resonance energy transfer, Signal detection, Bandpass filters

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PROCEEDINGS ARTICLE | February 17, 2009

A new red bimolecular fluorescence complementation based on TagRFP

Proc. SPIE. 7191, Fluorescence In Vivo Imaging Based on Genetically Engineered Probes: From Living Cells to Whole Body Imaging IV

KEYWORDS: Ferroelectric materials, Proteins, Visual analytics, Visualization, Luminescence, Chromophores, Signal processing, Molecular mechanisms, In vivo imaging, Fluorescent proteins

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PROCEEDINGS ARTICLE | February 17, 2009

Developing new fluorescent proteins with stagger extension process

Proc. SPIE. 7191, Fluorescence In Vivo Imaging Based on Genetically Engineered Probes: From Living Cells to Whole Body Imaging IV

KEYWORDS: Proteins, Biomedical optics, Green fluorescent protein, Luminescence, Quantum efficiency, Lutetium, Fluorescent proteins, Fluorescence resonance energy transfer, Mass attenuation coefficient, Venus

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SPIE Journal Paper | May 1, 2008

Activation of caspase-3 noninvolved in the bystander effect of the herpes simplex virus thymidine kinase gene/ganciclovir (HSV-tk/GCV) system

Zhang, Zhihong , Lin, Juqiang , Chu, Jun , Ma, Yan , Zeng, Shaoqun , Luo, Qingming

JBO Vol. 13 Issue 03

KEYWORDS: Fluorescence resonance energy transfer, Luminescence, Cell death, Multichannel imaging systems, Imaging systems, Green fluorescent protein, Proteins, Fluorescent proteins, Image fusion, Optoelectronics

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PROCEEDINGS ARTICLE | February 18, 2008

Simultaneous imaging of two initiator caspases during cisplatin-induced HeLa apoptosis

Proc. SPIE. 6857, Biophotonics and Immune Responses III

KEYWORDS: Proteins, Green fluorescent protein, Imaging systems, Image processing, Luminescence, Biosensors, Cell death, Digital image correlation, Fluorescent proteins, Fluorescence resonance energy transfer

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PROCEEDINGS ARTICLE | February 13, 2008

Caspase-3-independent pathways proceeding in bystander effect of HSV-tk/GCV system

Proc. SPIE. 6868, Small Animal Whole-Body Optical Imaging Based on Genetically Engineered Probes

KEYWORDS: Oncology, Cancer, Tumors, Visualization, Imaging systems, Luminescence, Cell death, Fluorescent proteins, Fluorescence resonance energy transfer, RGB color model

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PROCEEDINGS ARTICLE | February 13, 2008

Visualization of EGFR and Grb2 interaction using bimolecular fluorescence complementation

Proc. SPIE. 6868, Small Animal Whole-Body Optical Imaging Based on Genetically Engineered Probes

KEYWORDS: Proteins, Lithium, Green fluorescent protein, Visualization, Particles, Luminescence, Molecules, Receptors, Fluorescent proteins, Venus

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PROCEEDINGS ARTICLE | January 8, 2008

Measurement of caspase-2 activation during different anti-tumor drugs induced apoptosis by FRET technique

Proc. SPIE. 6826, Optics in Health Care and Biomedical Optics III

KEYWORDS: Proteins, Medicine, Biomedical optics, Cancer, Imaging systems, Optoelectronics, Photonics, Cell death, Fluorescent proteins, Fluorescence resonance energy transfer

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SPIE Journal Paper | January 1, 2008

Fluorescence imaging to assess the matrix metalloproteinase activity and its inhibitor in vivo

Zhang, Zhihong , Yang, Jie , Lu, Jinling , Lin, Juqiang , Zeng, Shaoqun , Luo, Qingming

JBO Vol. 13 Issue 01

KEYWORDS: Luminescence, Tumors, In vivo imaging, Sensors, Proteins, Fluorescence resonance energy transfer, Content addressable memory, Signal detection, Confocal microscopy, Imaging systems

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PROCEEDINGS ARTICLE | May 1, 2007

Photoinactivation of bacteria of P. Aeruginosa: role of light coherence

Proc. SPIE. 6534, Fifth International Conference on Photonics and Imaging in Biology and Medicine

KEYWORDS: Mathematical modeling, Temporal coherence, Laser therapeutics, Speckle, Molecules, Computer simulations, Oxygen, Molecular interactions, Laser tissue interaction, Bacteria

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PROCEEDINGS ARTICLE | February 13, 2007

Optical imaging the redox status change during cell apoptosis

Proc. SPIE. 6438, Biophotonics and Immune Responses II

KEYWORDS: Optical imaging, Confocal microscopy, Proteins, Green fluorescent protein, Imaging systems, Luminescence, Hydrogen, Oxygen, Cell death, In vivo imaging

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PROCEEDINGS ARTICLE | February 3, 2007

In vivo detecting matrix metalloproteinase (MMP) activity by a genetically engineered fluorescent probe

Proc. SPIE. 6449, Genetically Engineered and Optical Probes for Biomedical Applications IV

KEYWORDS: Optical filters, Proteins, Cancer, Tumors, Sensors, Luminescence, In vivo imaging, Fluorescence resonance energy transfer, Signal detection, Content addressable memory

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PROCEEDINGS ARTICLE | October 27, 2006

Monitoring apoptosis of TK-GFP-expressing ACC-M cells induced by ACV using FRET technique

Proc. SPIE. 6047, Fourth International Conference on Photonics and Imaging in Biology and Medicine

KEYWORDS: Proteins, Green fluorescent protein, Tumors, Tissues, Microscopy, Luminescence, Photonics, Cell death, Fluorescent proteins, Fluorescence resonance energy transfer

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SPIE Journal Paper | July 1, 2006

Real-time detection of caspase-2 activation in a single living HeLa cell during cisplatin-induced apoptosis

Lin, Juqiang , Zhang, Zhihong , Yang, Jie , Zeng, Shaoqun , Liu, Bifeng , Luo, Qingming

JBO Vol. 11 Issue 02

KEYWORDS: Fluorescence resonance energy transfer, Cell death, Proteins, Fluorescent proteins, In vitro testing, Luminescence, Spectroscopy, Imaging systems, Bacteria, Biomedical optics

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SPIE Journal Paper | July 1, 2006

Errata: Real-time detection of caspase-2 activation in a single living HeLa cell during cisplatin-induced apoptosis

Lin, Juqiang , Zhang, Zhihong , Zeng, Shaoqun , Liu, Bifeng , Luo, Qingming , Yang, Jie

JBO Vol. 11 Issue 04

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PROCEEDINGS ARTICLE | May 19, 2006

Monitoring apoptosis of TK-GFP-expressing ACC-M cells induced by ACV using FRET technique

Proc. SPIE. 6218, Chemical and Biological Sensing VII

KEYWORDS: Proteins, Green fluorescent protein, Tumors, Tissues, Microscopy, Luminescence, Cell death, Fluorescent proteins, Fluorescence resonance energy transfer, Cell mechanics

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PROCEEDINGS ARTICLE | February 22, 2006

Application of a FRET probe for Caspase-3 activation in living HeLa cells by sequentially treated cisplatin and TRAIL

Proc. SPIE. 6088, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues IV

KEYWORDS: Proteins, Cancer, Tumors, Tissues, Imaging systems, Luminescence, Cell death, Fluorescent proteins, Fluorescence resonance energy transfer, Resonance enhancement

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PROCEEDINGS ARTICLE | February 2, 2006

Real-time detecting gelatinases activity in living cells by FRET imaging

Proc. SPIE. 6026, ICO20: Biomedical Optics

KEYWORDS: Confocal microscopy, Proteins, Cancer, Tumors, Luminescence, Molecules, Fluorescence spectroscopy, Fluorescence resonance energy transfer, Signal detection, Fusion energy

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PROCEEDINGS ARTICLE | February 2, 2006

Imaging of caspase-3 activation by a novel FRET probe composed of CFP and DsRed

Proc. SPIE. 6026, ICO20: Biomedical Optics

KEYWORDS: Proteins, Cancer, Tumors, Luminescence, Chromium, Cell death, In vivo imaging, Fluorescent proteins, Fluorescence resonance energy transfer, Resonance enhancement

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PROCEEDINGS ARTICLE | June 22, 2005

Inactivation of bacterial cells by dynamic low-coherent speckles: mathematical model of photoprocessing

Proc. SPIE. 5771, Saratov Fall Meeting 2004: Optical Technologies in Biophysics and Medicine VI

KEYWORDS: Mathematical modeling, Medicine, Biomedical optics, Speckle, Molecules, Laser processing, Computer simulations, Oxygen, Microorganisms, Bacteria

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PROCEEDINGS ARTICLE | March 29, 2005

In vivo optical imaging of bacterial infection and antibiotic response in intact nude mice

Proc. SPIE. 5699, Imaging, Manipulation, and Analysis of Biomolecules and Cells: Fundamentals and Applications III

KEYWORDS: Optical imaging, Green fluorescent protein, Tumors, Visualization, Luminescence, Digital cameras, Abdomen, In vivo imaging, Whole body imaging, Bacteria

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PROCEEDINGS ARTICLE | January 18, 2005

Laser speckle contrast imaging: monitoring blood flow dynamics and vascular structure of photodynamic therapy

Proc. SPIE. 5630, Optics in Health Care and Biomedical Optics: Diagnostics and Treatment II

KEYWORDS: Photodynamic therapy, Tumors, Speckle, Blood, CCD cameras, Laser speckle contrast imaging, Speckle pattern, Blood circulation, In vivo imaging, Content addressable memory

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PROCEEDINGS ARTICLE | August 20, 2004

Imaging of tumor hypermetabolism with near-infrared fluorescence contrast agents

Proc. SPIE. 5474, Saratov Fall Meeting 2003: Optical Technologies in Biophysics and Medicine V

KEYWORDS: Breast, Near infrared, Tumors, Tissues, Imaging systems, Luminescence, Photons, Phased arrays, In vivo imaging, Signal detection

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SPIE Journal Paper | July 1, 2004

Redox ratio of mitochondria as an indicator for the response of photodynamic therapy

Zhang, Zhihong , Blessington, Dana , Li, Hui , Busch, Theresa , Glickson, Jerry , Luo, Qingming , Chance, Britton , Zheng, Gang

JBO Vol. 9 Issue 04

KEYWORDS: Tumors, Photodynamic therapy, Luminescence, Control systems, Flavoproteins, Oxygen, Tissues, Photography, Radiology, Tissue optics

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PROCEEDINGS ARTICLE | June 14, 2004

NIR optical probes targeting glucose transporters

Proc. SPIE. 5329, Genetically Engineered and Optical Probes for Biomedical Applications II

KEYWORDS: Confocal microscopy, Near infrared, Glucose, Liver, Cancer, Tumors, Tissues, Imaging systems, Luminescence, In vivo imaging

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PROCEEDINGS ARTICLE | December 8, 2003

Fluorescent imaging the characteristic of Pyro-2DG uptake in the normal tissue using the Cryo-Imager

Proc. SPIE. 5254, Third International Conference on Photonics and Imaging in Biology and Medicine

KEYWORDS: Optical fibers, Near infrared, Glucose, Liver, Tumors, Tissues, Luminescence, Tissue optics, Signal detection, Brain

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PROCEEDINGS ARTICLE | September 12, 2003

High-order photobleaching in two-photon excitation fluorescence microscopy inside live cell

Proc. SPIE. 4967, Genetically Engineered and Optical Probes for Biomedical Applications

KEYWORDS: Microscopes, Proteins, Multiphoton microscopy, Biomedical optics, Green fluorescent protein, Microscopy, Luminescence, Molecules, In vivo imaging, Multiphoton fluorescence microscopy

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PROCEEDINGS ARTICLE | July 29, 2003

Application of I&Q detection system in scouting the curative effect of neck squamous cell carcinoma

Proc. SPIE. 4955, Optical Tomography and Spectroscopy of Tissue V

KEYWORDS: Neck, Cancer, Tumors, Blood, Skin, Imaging spectroscopy, Radiotherapy, Near infrared spectroscopy, Tissue optics, Absorption

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PROCEEDINGS ARTICLE | July 29, 2003

NIR imaging the delivery of cathepsin B probe to breast tumors

Proc. SPIE. 4955, Optical Tomography and Spectroscopy of Tissue V

KEYWORDS: Near infrared, Light sources, Veins, Tumors, Tissues, Blood vessels, Luminescence, Semiconductor lasers, Data processing, Natural surfaces

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PROCEEDINGS ARTICLE | July 29, 2003

Detection and imaging of the reconstituted pyropheophorbide-cholesterol oleate labeled low-density lipoprotein in the HepG2 tumor

Proc. SPIE. 4955, Optical Tomography and Spectroscopy of Tissue V

KEYWORDS: Optical filters, Veins, Tumors, Tissues, Imaging systems, Blood vessels, Luminescence, Melanoma, Receptors, Signal detection

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PROCEEDINGS ARTICLE | July 29, 2003

Determination of subsurface tumor localization in animal models with near-infrared (NIR) fluorescence imaging

Proc. SPIE. 4955, Optical Tomography and Spectroscopy of Tissue V

KEYWORDS: Breast, Near infrared, Tumors, Imaging systems, Scattering, Luminescence, Phased arrays, In vivo imaging, Signal detection, Animal model studies

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PROCEEDINGS ARTICLE | April 12, 2002

In-vivo optical molecular imaging for laser hyperthermia

Proc. SPIE. 4536, International Workshop on Photonics and Imaging in Biology and Medicine

KEYWORDS: Microscopes, Proteins, Green fluorescent protein, Tumors, Imaging systems, Image processing, Luminescence, Molecular imaging, In vivo imaging, Neurons

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PROCEEDINGS ARTICLE | April 12, 2002

5-HT spatial distribution imaging with multiphoton excitation of 5-HT correlative visible fluorescence in live cells

Proc. SPIE. 4536, International Workshop on Photonics and Imaging in Biology and Medicine

KEYWORDS: Microscopes, Visible radiation, Tissues, Mode locking, Ultraviolet radiation, Luminescence, Photons, Laser scanners, Live cell imaging, Spatial resolution

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PROCEEDINGS ARTICLE | April 12, 2002

Detection of calcium by a confocal laser scanning microscope in Na2SeO3-treated SW480 human colonic carcinoma cells

Proc. SPIE. 4536, International Workshop on Photonics and Imaging in Biology and Medicine

KEYWORDS: Confocal microscopy, Microscopes, Medicine, Calcium, Laser scanners, Biology, Photonics, Cell death, Sodium, Selenium

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PROCEEDINGS ARTICLE | August 22, 2001

Spatio-temporal characterization imaging of Ca2+ oscillations in rat hippocampal neurons

Proc. SPIE. 4427, Imaging of Tissue Structure and Function

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PROCEEDINGS ARTICLE | August 22, 2001

Novel photobleaching model in living cells

Proc. SPIE. 4427, Imaging of Tissue Structure and Function

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PROCEEDINGS ARTICLE | October 11, 2000

Data analysis in green-fluorescent-protein-based fluorescence resonance energy transfer

Proc. SPIE. 4224, Biomedical Photonics and Optoelectronic Imaging

KEYWORDS: Biomedical optics, Green fluorescent protein, Luminescence, Fluorescence spectroscopy, Calcium, Time metrology, Photonics, Image filtering, Fluorescence resonance energy transfer, Data analysis

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Showing 5 of 49 publications

Conference Committee Involvement (5)

Biophotonics and Immune Responses XIV

4 February 2019 | San Francisco, California, United States

Biophotonics and Immune Responses XIII

29 January 2018 | San Francisco, California, United States

Biophotonics and Immune Responses XII

30 January 2017 | San Francisco, California, United States

Biophotonics and Immune Responses XI

15 February 2016 | San Francisco, California, United States

Biophotonics and Immune Responses X

9 February 2015 | San Francisco, California, United States

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