Prof. Zhihong Zhang Profile

Prof. Zhihong Zhang

Professor at Wuhan National Research Ctr for Optoelectronics

SPIE Involvement:

Conference Program Committee | Author

Publications (53)

Proceedings Article | 7 March 2019 Presentation + Paper

ALDH3A2 as a potential molecular marker for nasopharyngeal carcinoma

Shuhong Qi, Lisen Lu, Zhihong Zhang

Proc. SPIE. 10879, Biophotonics and Immune Responses XIV

KEYWORDS: Proteins, Nanoparticles, Receptors, Confocal microscopy, Signal detection, Statistical analysis, Flow cytometry, Target detection, Biological research, Cancer

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Proceedings Article | 7 March 2019 Presentation

Targeting delivery of nanovaccine/nanoimmunomudulator based on peptide-lipid nanoparticle for immunotherapy in vivo (Conference Presentation)

Zhihong Zhang, Lisen Lu, Yuan Qian, Sha Qiao, Qingming Luo

Proc. SPIE. 10879, Biophotonics and Immune Responses XIV

KEYWORDS: Nanoparticles, In vivo imaging, Tumors, Melanoma, Lymphatic system, Cancer, Therapeutic agents, Near infrared, Receptors

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SPIE Journal Paper | 1 March 2019

Dynamic visualization of the whole process of cytotoxic T lymphocytes killing B16 tumor cells in vitro

Shuhong Qi, Hua Shi, Lei Liu, Lili Zhou, Zhihong Zhang

JBO Vol. 24 Issue 05

KEYWORDS: Tumors, In vitro testing, Visualization, Confocal microscopy, Signal detection, Cancer, Target recognition, Cell death, Flow cytometry, Video

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Proceedings Article | 19 April 2017 Presentation

A lipid-based nano-regulator for cancer immunotherapy (Conference Presentation)

Yuan Qian, Sha Qiao, Zhihong Zhang

Proc. SPIE. 10065, Biophotonics and Immune Responses XII

KEYWORDS: Tumors, Biomedical optics, Current controlled current source, Cancer, Nanotechnology, Nanoparticles, Lymphatic system, Molecules

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Proceedings Article | 19 April 2017 Presentation

Dynamical optical imaging monocytes/macrophages migration and activation in contact hypersensitivity (Conference Presentation)

Zhihong Zhang

Proc. SPIE. 10065, Biophotonics and Immune Responses XII

KEYWORDS: Biomedical optics, Optical imaging, Inflammation, Molecular imaging, In vivo imaging, Mouse models, Fluorescent proteins, Skin, Microscopy, Blood

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Proceedings Article | 15 March 2016 Paper

CT/FMT dual-model imaging of breast cancer based on peptide-lipid nanoparticles

Guoqiang Xu, Qiaoya Lin, Lichao Lian, Yuan Qian, Lisen Lu, Zhihong Zhang

Proc. SPIE. 9709, Biophotonics and Immune Responses XI

KEYWORDS: Nanoparticles, Tissues, Breast cancer, Mammography, Cancer, X-ray computed tomography, 3D acquisition, Luminescence, Fluorescence tomography, Tomography, Tumors, Breast, In vivo imaging, In vitro testing

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Proceedings Article | 15 March 2016 Presentation + Paper

Dynamic visualization the whole process of cytotoxic T lymphocytes killing the B16 tumor cells in vitro

Shuhong Qi, Zhihong Zhang

Proc. SPIE. 9709, Biophotonics and Immune Responses XI

KEYWORDS: Tumors, Confocal microscopy, In vitro testing, Visualization, Signal detection, Flow cytometry, Imaging systems, Statistical analysis, Biomedical optics, Cancer

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Proceedings Article | 9 March 2015 Paper

Intravital imaging of multicolor-labeled tumor immune microenvironment through skin-fold window chamber

Shuhong Qi, Zhihong Zhang

Proc. SPIE. 9324, Biophotonics and Immune Responses X

KEYWORDS: Tumors, Fluorescent proteins, Signal detection, Biomedical optics, Microscopy, Photonics, Data analysis, Video, In vivo imaging, 3D image processing

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Proceedings Article | 9 March 2015 Paper

Tumor redox metabolism correlation with the expression level of red fluorescent protein

Shuang Sha, Anle Wang, Qiaoya Lin, Zhihong Zhang

Proc. SPIE. 9324, Biophotonics and Immune Responses X

KEYWORDS: Tumors, Mode conditioning cables, Fluorescent proteins, Proteins, Tumor growth modeling, Luminescence, Melanoma, Cancer, Scanners, Tissues

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Proceedings Article | 5 March 2014 Paper

Impact of rapamycin on phenotype and tolerogenic function of dendritic cells via intravital optical imaging

Meijie Luo, Zhihong Zhang

Proc. SPIE. 8944, Biophotonics and Immune Responses IX

KEYWORDS: In vitro testing, Lymphatic system, Statistical analysis, Molecules, Optical imaging, Tolerancing, Confocal microscopy, Transplantation, Tissues, Bone

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Proceedings Article | 27 February 2014 Paper

Metabolic imaging of the tumor treated by KillerRed fluorescent protein-based photodynamic therapy in mice

Shuang Sha, Lingsong Qin, Anle Wang, Zheng Liu, Fei Yang, Honglin Jin, Zhihong Zhang

Proc. SPIE. 8944, Biophotonics and Immune Responses IX

KEYWORDS: Tumors, Photodynamic therapy, Flavoproteins, Proteins, Mode conditioning cables, Luminescence, Fluorescent proteins, Oxygen, In vivo imaging, Biomedical optics

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SPIE Journal Paper | 27 January 2014

Preclinical evidence of mitochondrial nicotinamide adenine dinucleotide as an effective alarm parameter under hypoxia

Hua Shi, Nannan Sun, Avraham Mayevsky, Zhihong Zhang, Qingming Luo

JBO Vol. 19 Issue 01

KEYWORDS: Hypoxia, Electrocardiography, Reflectivity, Oxygen, Tissues, Luminescence, Brain, Cerebral blood flow, Arteries, Nitrogen

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SPIE Journal Paper | 9 July 2012

Real-time imaging elucidates the role of H2O2 in regulating kinetics of epidermal growth factor-induced and Src-mediated tyrosine phosphorylation signaling

Ting Su, Xiangyong Li, Nisha Liu, Shaotao Pan, Jinling Lu, Jie Yang, Zhihong Zhang

JBO Vol. 17 Issue 7

KEYWORDS: Biosensors, Proteins, Control systems, Real time imaging, Modulation, Signal attenuation, Fluorescence resonance energy transfer, Fluorescent proteins, Image processing, Oxidation

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SPIE Journal Paper | 5 June 2012

Monitoring the process of pulmonary melanoma metastasis using large area and label-free nonlinear optical microscopy

Daozhu Hua, Shuhong Qi, Hui Li, Zhihong Zhang, Ling Fu

JBO Vol. 17 Issue 06

KEYWORDS: Tissues, Second-harmonic generation, Melanoma, Cancer, Lung, Collagen, Nano opto mechanical systems, Microscopy, Optical microscopy, Tumors

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Proceedings Article | 6 March 2009 Paper

Five-color fluorescent imaging in living tumor cells

Liang Wang, Jie Yang, Jun Chu, Qingming Luo, Zhihong Zhang

Proc. SPIE. 7280, Seventh International Conference on Photonics and Imaging in Biology and Medicine

KEYWORDS: Fluorescent proteins, Confocal microscopy, Luminescence, Proteins, Tumors, Bandpass filters, Photonics, Imaging technologies, Plasma, Glasses

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Proceedings Article | 25 February 2009 Paper

Real-time optical imaging of the interaction of epidermal growth factor and its receptor in living cells

Qiaoya Lin, Liang Wang, Shaoqun Zeng, Zhihong Zhang, Gang Zheng

Proc. SPIE. 7178, Biophotonics and Immune Responses IV

KEYWORDS: Fluorescence resonance energy transfer, Receptors, Green fluorescent protein, Signal detection, Visualization, Optical imaging, Proteins, Molecules, Bandpass filters, Cancer

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Proceedings Article | 17 February 2009 Paper

Developing new fluorescent proteins with stagger extension process

Jie Yang, Jinling Lu, Haiming Luo, Qingming Luo, Zhihong Zhang

Proc. SPIE. 7191, Fluorescence In Vivo Imaging Based on Genetically Engineered Probes: From Living Cells to Whole Body Imaging IV

KEYWORDS: Luminescence, Proteins, Fluorescent proteins, Green fluorescent protein, Quantum efficiency, Venus, Biomedical optics, Fluorescence resonance energy transfer, Mass attenuation coefficient, Lutetium

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Proceedings Article | 17 February 2009 Paper

A new red bimolecular fluorescence complementation based on TagRFP

Lingsong Qin, Jun Chu, Ying Zheng, Qingming Luo, Shaoqun Zeng, Zhihong Zhang

Proc. SPIE. 7191, Fluorescence In Vivo Imaging Based on Genetically Engineered Probes: From Living Cells to Whole Body Imaging IV

KEYWORDS: Luminescence, Proteins, Fluorescent proteins, Ferroelectric materials, In vivo imaging, Visualization, Visual analytics, Chromophores, Molecular mechanisms, Signal processing

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SPIE Journal Paper | 1 May 2008

Activation of caspase-3 noninvolved in the bystander effect of the herpes simplex virus thymidine kinase gene/ganciclovir (HSV-tk/GCV) system

Zhihong Zhang, Juqiang Lin, Jun Chu, Yan Ma, Shaoqun Zeng, Qingming Luo

JBO Vol. 13 Issue 03

KEYWORDS: Fluorescence resonance energy transfer, Luminescence, Cell death, Multichannel imaging systems, Imaging systems, Green fluorescent protein, Proteins, Fluorescent proteins, Image fusion, Optoelectronics

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Proceedings Article | 18 February 2008 Paper

Simultaneous imaging of two initiator caspases during cisplatin-induced HeLa apoptosis

Jun Chu, Liang Wang, Qingming Luo, Zhihong Zhang

Proc. SPIE. 6857, Biophotonics and Immune Responses III

KEYWORDS: Cell death, Fluorescence resonance energy transfer, Fluorescent proteins, Luminescence, Proteins, Biosensors, Green fluorescent protein, Imaging systems, Image processing, Digital image correlation

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Proceedings Article | 13 February 2008 Paper

Visualization of EGFR and Grb2 interaction using bimolecular fluorescence complementation

Xiangyong Li, Jun Chu, Qingming Luo, Zhihong Zhang

Proc. SPIE. 6868, Small Animal Whole-Body Optical Imaging Based on Genetically Engineered Probes

KEYWORDS: Proteins, Visualization, Luminescence, Receptors, Venus, Fluorescent proteins, Particles, Green fluorescent protein, Molecules, Lithium

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Proceedings Article | 13 February 2008 Paper

Caspase-3-independent pathways proceeding in bystander effect of HSV-tk/GCV system

Juqiang Lin, Yan Ma, Shaoqun Zeng, Zhihong Zhang

Proc. SPIE. 6868, Small Animal Whole-Body Optical Imaging Based on Genetically Engineered Probes

KEYWORDS: Fluorescence resonance energy transfer, Cell death, Imaging systems, Cancer, Tumors, Oncology, Fluorescent proteins, Visualization, Luminescence, RGB color model

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Proceedings Article | 8 January 2008 Paper

Measurement of caspase-2 activation during different anti-tumor drugs induced apoptosis by FRET technique

Juqiang Lin, Shaoqun Zeng, Qingming Luo, Chen Rong, Zhihong Zhang

Proc. SPIE. 6826, Optics in Health Care and Biomedical Optics III

KEYWORDS: Fluorescence resonance energy transfer, Cell death, Fluorescent proteins, Cancer, Biomedical optics, Proteins, Optoelectronics, Imaging systems, Medicine, Photonics

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SPIE Journal Paper | 1 January 2008

Fluorescence imaging to assess the matrix metalloproteinase activity and its inhibitor in vivo

Zhihong Zhang, Jie Yang, Jinling Lu, Juqiang Lin, Shaoqun Zeng, Qingming Luo

JBO Vol. 13 Issue 01

KEYWORDS: Luminescence, Tumors, In vivo imaging, Sensors, Proteins, Fluorescence resonance energy transfer, Content addressable memory, Signal detection, Confocal microscopy, Imaging systems

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Proceedings Article | 1 May 2007 Paper

Photoinactivation of bacteria of P. Aeruginosa: role of light coherence

Onega Ulianova, Sibo Zhou, Zhihong Zhang, Sergey Ulyanov, Qingming Luo

Proc. SPIE. 6534, Fifth International Conference on Photonics and Imaging in Biology and Medicine

KEYWORDS: Oxygen, Molecules, Bacteria, Molecular interactions, Speckle, Mathematical modeling, Laser tissue interaction, Laser therapeutics, Temporal coherence, Computer simulations

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Proceedings Article | 13 February 2007 Paper

Optical imaging the redox status change during cell apoptosis

Ting Su, Zhihong Zhang, Juqiang Lin, Qingming Luo

Proc. SPIE. 6438, Biophotonics and Immune Responses II

KEYWORDS: Cell death, Luminescence, Oxygen, Green fluorescent protein, Confocal microscopy, Imaging systems, Proteins, Hydrogen, Optical imaging, In vivo imaging

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Proceedings Article | 3 February 2007 Paper

In vivo detecting matrix metalloproteinase (MMP) activity by a genetically engineered fluorescent probe

Jie Yang, Zhihong Zhang, Ting Su, Qingming Luo

Proc. SPIE. 6449, Genetically Engineered and Optical Probes for Biomedical Applications IV

KEYWORDS: Luminescence, Tumors, Content addressable memory, Sensors, Fluorescence resonance energy transfer, Proteins, Signal detection, In vivo imaging, Optical filters, Cancer

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Proceedings Article | 27 October 2006 Paper

Monitoring apoptosis of TK-GFP-expressing ACC-M cells induced by ACV using FRET technique

Tao Xiong, Zhihong Zhang, Juqiang Lin, Jie Yang, Shaoqun Zeng, Qingming Luo

Proc. SPIE. 6047, Fourth International Conference on Photonics and Imaging in Biology and Medicine

KEYWORDS: Fluorescence resonance energy transfer, Cell death, Tumors, Fluorescent proteins, Green fluorescent protein, Tissues, Proteins, Luminescence, Microscopy, Photonics

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SPIE Journal Paper | 1 July 2006

Real-time detection of caspase-2 activation in a single living HeLa cell during cisplatin-induced apoptosis

Juqiang Lin, Zhihong Zhang, Jie Yang, Shaoqun Zeng, Bifeng Liu, Qingming Luo

JBO Vol. 11 Issue 02

KEYWORDS: Fluorescence resonance energy transfer, Cell death, Proteins, Fluorescent proteins, In vitro testing, Luminescence, Spectroscopy, Imaging systems, Bacteria, Biomedical optics

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SPIE Journal Paper | 1 July 2006

Errata: Real-time detection of caspase-2 activation in a single living HeLa cell during cisplatin-induced apoptosis

Juqiang Lin, Zhihong Zhang, Shaoqun Zeng, Bifeng Liu, Qingming Luo, Jie Yang

JBO Vol. 11 Issue 04

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Proceedings Article | 19 May 2006 Paper

Monitoring apoptosis of TK-GFP-expressing ACC-M cells induced by ACV using FRET technique

Tao Xiong, Zhihong Zhang, Juqiang Lin, Jie Yang, Shaoqun Zeng, Qingming Luo

Proc. SPIE. 6218, Chemical and Biological Sensing VII

KEYWORDS: Fluorescence resonance energy transfer, Cell death, Tumors, Green fluorescent protein, Fluorescent proteins, Tissues, Proteins, Luminescence, Microscopy, Cell mechanics

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Proceedings Article | 22 February 2006 Paper

Application of a FRET probe for Caspase-3 activation in living HeLa cells by sequentially treated cisplatin and TRAIL

Juqiang Lin, Zhihong Zhang, Qiushi Yi, Shaoqun Zeng, Qingming Luo

Proc. SPIE. 6088, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues IV

KEYWORDS: Fluorescence resonance energy transfer, Cell death, Proteins, Tumors, Cancer, Luminescence, Fluorescent proteins, Imaging systems, Resonance enhancement, Tissues

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Proceedings Article | 2 February 2006 Paper

Imaging of caspase-3 activation by a novel FRET probe composed of CFP and DsRed

Juquiang Lin, Zhihong Zhang, Bifeng Liu, Qingming Luo

Proc. SPIE. 6026, ICO20: Biomedical Optics

KEYWORDS: Fluorescence resonance energy transfer, Cell death, Fluorescent proteins, Proteins, Luminescence, In vivo imaging, Chromium, Resonance enhancement, Tumors, Cancer

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Proceedings Article | 2 February 2006 Paper

Real-time detecting gelatinases activity in living cells by FRET imaging

Jie Yang, Zhihong Zhang, Bifeng Liu, Qingming Luo

Proc. SPIE. 6026, ICO20: Biomedical Optics

KEYWORDS: Fluorescence resonance energy transfer, Luminescence, Proteins, Tumors, Cancer, Signal detection, Fluorescence spectroscopy, Confocal microscopy, Fusion energy, Molecules

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Proceedings Article | 22 June 2005 Paper

Inactivation of bacterial cells by dynamic low-coherent speckles: mathematical model of photoprocessing

Onega Ulianova, Sergey Ulyanov, Elena Sazanova, Zhihong Zhang, Sibo Zhou, Qingming Luo, Irina Zudina, Andrey Bednov

Proc. SPIE. 5771, Saratov Fall Meeting 2004: Optical Technologies in Biophysics and Medicine VI

KEYWORDS: Bacteria, Oxygen, Mathematical modeling, Molecules, Speckle, Computer simulations, Laser processing, Medicine, Microorganisms, Biomedical optics

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Proceedings Article | 29 March 2005 Paper

In vivo optical imaging of bacterial infection and antibiotic response in intact nude mice

Tao Xiong, Yanping Chen, Jun Chu, Zhihong Zhang, Bifeng Liu, Qingming Luo

Proc. SPIE. 5699, Imaging, Manipulation, and Analysis of Biomolecules and Cells: Fundamentals and Applications III

KEYWORDS: Bacteria, Luminescence, Whole body imaging, Green fluorescent protein, In vivo imaging, Digital cameras, Abdomen, Visualization, Tumors, Optical imaging

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Proceedings Article | 18 January 2005 Paper

Laser speckle contrast imaging: monitoring blood flow dynamics and vascular structure of photodynamic therapy

Qian Liu, Sibo Zhou, Zhihong Zhang, Qingming Luo

Proc. SPIE. 5630, Optics in Health Care and Biomedical Optics: Diagnostics and Treatment II

KEYWORDS: Speckle, Photodynamic therapy, Laser speckle contrast imaging, Blood circulation, Content addressable memory, In vivo imaging, Blood, Tumors, Speckle pattern, CCD cameras

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Proceedings Article | 20 August 2004 Paper

Imaging of tumor hypermetabolism with near-infrared fluorescence contrast agents

Yu Chen, Gang Zheng, Zhihong Zhang, Dana Blessington, Xavier Intes, Samuel Achilefu, Britton Chance

Proc. SPIE. 5474, Saratov Fall Meeting 2003: Optical Technologies in Biophysics and Medicine V

KEYWORDS: Tumors, Luminescence, Imaging systems, Tissues, Photons, Breast, In vivo imaging, Phased arrays, Signal detection, Near infrared

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SPIE Journal Paper | 1 July 2004

Redox ratio of mitochondria as an indicator for the response of photodynamic therapy

Zhihong Zhang, Dana Blessington, Hui Li, Theresa Busch, Jerry Glickson, Qingming Luo, Britton Chance, Gang Zheng

JBO Vol. 9 Issue 04

KEYWORDS: Tumors, Photodynamic therapy, Luminescence, Control systems, Flavoproteins, Oxygen, Tissues, Photography, Radiology, Tissue optics

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Proceedings Article | 14 June 2004 Paper

NIR optical probes targeting glucose transporters

Hui Li, Juan Chen, Min Zhang, Zhihong Zhang, David Benaron, Britton Chance, Jerry Glickson, Gang Zheng

Proc. SPIE. 5329, Genetically Engineered and Optical Probes for Biomedical Applications II

KEYWORDS: Tumors, Near infrared, Cancer, In vivo imaging, Glucose, Confocal microscopy, Luminescence, Imaging systems, Liver, Tissues

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Proceedings Article | 8 December 2003 Paper

Fluorescent imaging the characteristic of Pyro-2DG uptake in the normal tissue using the Cryo-Imager

Zhihong Zhang, Dana Blessington, Gang Zheng, Qingming Luo, Britton Chance

Proc. SPIE. 5254, Third International Conference on Photonics and Imaging in Biology and Medicine

KEYWORDS: Liver, Tissues, Tumors, Signal detection, Near infrared, Tissue optics, Luminescence, Glucose, Brain, Optical fibers

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Proceedings Article | 12 September 2003 Paper

High-order photobleaching in two-photon excitation fluorescence microscopy inside live cell

Tongsheng Chen, Shaoqun Zeng, Qingming Luo, Wei Zhou, Zhihong Zhang

Proc. SPIE. 4967, Genetically Engineered and Optical Probes for Biomedical Applications

KEYWORDS: Luminescence, Microscopy, Green fluorescent protein, Multiphoton microscopy, In vivo imaging, Molecules, Proteins, Multiphoton fluorescence microscopy, Biomedical optics, Microscopes

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Proceedings Article | 29 July 2003 Paper

NIR imaging the delivery of cathepsin B probe to breast tumors

Lanlan Zhou, Dana Blessington, Zhihong Zhang, Aristid Lindenmayer, Ching Tung, Ralph Weissleder, Britton Chance