Semiconductor quantum dots (QDs) having high quantum yields and unique photostability. This research studies the optical properties of the synthesized CdTe QDs with two different sizes using Laser induced fluorescence for investigating their photostability. TEM images illustrate that the two prepared QDs sizes are 2.4 and 3.5 nm. FTIR analysis revealed that the prepared QD capped with oleic acid. LIF technique showed that there is a red shift of the fluorescence emission of the bigger size QDs compared to the smaller one. The small size QD has a lower photostability when compared to the big size 2.4 nm. This study introduces guidance adapting CdTe photophysical properties for generalized applications especially biological laser imaging and solar cell applications.