Advanced volumetric data three-dimensional (3D) display can provide depth cues than conventional two-dimensional. Here, an algorithm of view frustum shear transformation and ray casting integral to realize real-time volume data 3D display is presented. It is compatible with the existing volume drawing pipeline and robust for other types of 3D displays. Experimental results demonstrate that the volume data is clearly represented, and real-time frame rate is more than 30 fps under the condition of subpixel-level at 4K (3840×2160) resolution. Besides, its performance does not rely on the viewpoint number and viewing angle, therefore, it is very suitable for 3D display of large viewing angles and dense viewpoints.