A high power, high-repetition picosecond amplifier with an all-fiber picoseconds seed source, Nd:YVO<sub>4</sub> and Nd:YAG gain medium was designed and experimentally studied. For a injected seeder laser with a repetition rate of 1 MHz and an average power of 2.34 W, a 55 W laser power output was obtained by the two-stage solid-state amplification, and the measured pulse width was 9.2 ps, and the laser wavelength was 1064.5 nm. The laser output characteristics of different repetitive modes were experimentally studied, and the laser output power was 18.4 W in the (1 × 4) MHz burst mode. Since the spectrum of the fiber picosecond seed light is much larger than the gain spectrum width of the amplifying medium, the output power of the entire system does not reach the design index. Next, the fiber seed source parameters need to be optimized to achieve a larger amplification power output.