An Infrared Imaging Pretreatment System was designed based on Xilinx Zynq-7000 Extensible Processing Platform (EPP). Zynq-7000 integrate a dual-core ARM Cortex-A9 based processing system (PS) and programmable logic (PL) in a single device. In this design, PL was developed for IRFPA video signal acquisition, and used VIDEO_IN, VIDEO_OUT, AXI-VDMA IP core to build high speed data channel between PS and PL. PS was developed for Imaging Pretreatment such as Non-uniformity correction, Blind pixels compensation and Image enhancement, using DDR3 for PS’ external memory and PL for Camera Link/PAL video output. It’s optimized for powerful, high real-time, small size, low-power and high reliability, to reach the goal of mass production in work.