Proceedings Article | 29 February 2016
KEYWORDS: Near infrared, Reliability, Signal to noise ratio, Near infrared spectroscopy, Data analysis, Diagnostics, Data processing, Interference (communication), Signal processing, Signal detection
Bone marrow is an important hematopoietic organ, and bone marrow lesions (BMLs) may cause a variety of
complications with high death rate and short survival time. Early detection and follow up care are particularly important.
But the current diagnosis methods rely on bone marrow biopsy/puncture, with significant limitations such as invasion,
complex operation, high risk, and discontinuous. It is highly in need of a non-invasive, safe, easily operated, and
continuous monitoring technology. So we proposed to design a device aimed for detecting bone marrow lesions, which
was based on near infrared spectrum technology. Then we fully tested its reliabilities, including the sensitivity, specificity,
signal-to-noise ratio (SNR), stability, and etc. Here, we reported this sequence of reliability test experiments, the
experimental results, and the following data analysis. This instrument was shown to be very sensitive, with
distinguishable concentration less than 0.002 and with good linearity, stability and high SNR. Finally, these
reliability-test data supported the promising clinical diagnosis and surgery guidance of our novel instrument in detection
of BMLs.
