Prof. Zhen Yuan Profile

Prof. Zhen Yuan

Professor at Univ of Macau

SPIE Involvement:

Author

Area of Expertise:

photoacoustic tomography , optical molecular imaging , fNIRS , cancer theranostics , Multi-modality imaging , neuroscience

Websites:

Personal Website | Company Website

Profile Summary

Dr. Zhen Yuan, is now a full professor with the Faculty of Health Sciences at the University of Macau. His academic investigation is focused on biomedical optics, neurophotonics and optical molecular imaging. He has achieved national and international recognition through more than 200 SCI publications in high ranked journals in his field such as Advanced Functional Materials, Small，Nano Letters, ACS Nano, Biomaterials, Chemical Science, Angewandte Chemie International Edition, Theranostics, ACS Appl. Mater. Interfaces, Journal of Biomedical Optics, Neurophotonics, Biophotonics, Optics Letters, Optics Express, and Applied Physics Letters. He is the editorial board member of Quantitative Imaging in Medicine and Surgery, associate editor of BMC Medical Imaging, and associate editor of Frontiers in Human Neuroscience. He is a senior member of OSA and senior member of SPIE since 2008.

Publications (41)

SPIE Journal Paper | 18 May 2023 Open Access

Open Access

Behavioral modeling and neuroimaging of impaired risky decision making in patients with chronic musculoskeletal pain

Xinglin Zeng, Wen Tang, Fei Gao, Ziyue Tang, Zhou Zhang, Juan Zhang, Meng Du, Zhiyi Chen, Xueli Chen, Zhen Yuan

NPh, Vol. 10, Issue 02, 020901, (May 2023) https://doi.org/10.1117/12.10.1117/1.NPh.10.2.020901

KEYWORDS: Decision making, Neuroimaging, Balloons, Modeling, Machine learning, Cognitive modeling, Neurophotonics, Brain, Performance modeling, Inspection

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Proceedings Article | 21 February 2020 Presentation + Paper

Presentation + Paper

Using fNIRS to study the brain activation and networks associated with Chinese character recognition

Zhen Yuan, Zhishan Hu

Proceedings Volume 11226, 112260C (2020) https://doi.org/10.1117/12.2542231

KEYWORDS: Brain, Brain activation, Visualization, Optical character recognition, Data processing, Network security, Legal, Binary data, Signal processing, Synthetic aperture radar

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Proceedings Article | 21 February 2020 Presentation + Paper

Presentation + Paper

Protein-modified CuS nanotriangles for dual-modal photoacoustic and magnetic resonance imaging

Zhen Yuan, Duyang Gao

Proceedings Volume 11254, 112540K (2020) https://doi.org/10.1117/12.2542233

KEYWORDS: Copper, Nanoprobes, Nanostructures, Magnetic resonance imaging, In vivo imaging, Tumors, Absorption, Photoacoustic spectroscopy, Gadolinium, Absorbance

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Proceedings Article | 17 February 2020 Presentation + Paper

Presentation + Paper

Optical mapping of effective brain networks during the tangram task

Zhishan Hu, Zhen Yuan, Keng-Fong Lam

Proceedings Volume 11225, 1122507 (2020) https://doi.org/10.1117/12.2542229

KEYWORDS: Silver, Brain, Brain activation, Inspection, Neuroimaging, Visualization, Prefrontal cortex, Cortical activation, Brain mapping, Sensors

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Although the neural basis underlying visuospatial reasoning has been widely explored by neuroimaging techniques, the brain activation patterns during naturalistic visuospatial reasoning such as tangram remains unclear. In this study, the directional functional connectivity of fronto-parietal networks during the tangram task was carefully inspected by using combined functional near-infrared spectroscopy (fNIRS) and conditional Granger causality analysis (GCA). Meanwhile, the causal networks during the traditional spatial reasoning task were also characterized to exhibit the differences with those during the tangram task. We discovered that the tangram task in a natural environment showed enhanced activation in the fronto-parietal regions, particularly the frontal cortex. In addition, a strong directional connectivity from the right prefrontal cortex to left angular gyrus was detected for the complex spatial reasoning condition of spatial reasoning task, whereas no effective connectivity was identified between the frontal and parietal cortices during the tangram task. Further correlation analyses showed that the behavioral performance in the spatial reasoning rather than the tangram task manifested the relationship with the connectivity between the frontal and parietal cortex. Our findings demonstrate that the tangram task measures a different aspect of the visuospatial reasoning ability which requires more trial-and-error strategies and creative thinking rather than inductive reasoning. In particular, the frontal cortex is mostly involved in tangram puzzle-solving, whereas the interaction between frontal and parietal cortices might be disrupted by the hands-on experience during the tangram task. Our study also indicates that conditional GCA combined with fNIRS neuroimaging technique is a robust tool for constructing the causal networks associated with natural visuospatial reasoning, which paves a new avenue for an improved understanding of the neural mechanism underlying tangram

SPIE Journal Paper | 4 June 2019 Open Access

Open Access

Abnormal dynamic functional connectivity and brain states in Alzheimer’s diseases: functional near-infrared spectroscopy study

Haijing Niu, Zhaojun Zhu, Mengjing Wang, Xuanyu Li, Zhen Yuan, Yu Sun, Ying Han

NPh, Vol. 6, Issue 02, 025010, (June 2019) https://doi.org/10.1117/12.10.1117/1.NPh.6.2.025010

KEYWORDS: Brain, Alzheimer's disease, Near infrared spectroscopy, Neuroimaging, Neurophotonics, Dementia, Control systems, Brain mapping, Visualization, Data acquisition

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SPIE Journal Paper | 15 May 2019 Open Access

Open Access

Linking brain activation to topological organization in the frontal lobe as a synergistic indicator to characterize the difference between various cognitive processes of executive functions

Zhishan Hu, Juan Zhang, Lingyan Zhang, Yu-Tao Xiang, Zhen Yuan

NPh, Vol. 6, Issue 02, 025008, (May 2019) https://doi.org/10.1117/12.10.1117/1.NPh.6.2.025008

KEYWORDS: Brain activation, Switches, Brain, Staring arrays, Neurophotonics, Inspection, Network architectures, Lab on a chip, Near infrared spectroscopy, Neuroimaging

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Proceedings Article | 7 March 2019 Presentation + Paper

Presentation + Paper

Using multispectral photoacoustic tomography for imaging scleroderma in the hand

Zhen Yuan, Yubin Liu

Proceedings Volume 10863, 108630D (2019) https://doi.org/10.1117/12.2508314

KEYWORDS: Skin, Tissues, Blood vessels, Magnetic resonance imaging, Acquisition tracking and pointing, Control systems, Photoacoustic tomography, Imaging systems, Photoacoustic imaging, Statistical analysis

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Proceedings Article | 5 March 2019 Presentation + Paper

Presentation + Paper

Highly stable conjugated polymer dots as multifunctional agents for photoacoustic imaging-guided photothermal therapy

Zhen Yuan, Kaiwen Chang

Proceedings Volume 10891, 1089113 (2019) https://doi.org/10.1117/12.2508296

KEYWORDS: Tumors, In vivo imaging, Polymers, Laser irradiation, Cancer, Absorption, Nanomaterials, Photoacoustic spectroscopy, In vitro testing, Nanostructures

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Proceedings Article | 1 March 2019 Presentation + Paper

Presentation + Paper

Mapping of the brain activation associated with deception using fused EEG and fNIRS

Zhen Yuan, Xiaohong Lin

Proceedings Volume 10865, 108650D (2019) https://doi.org/10.1117/12.2508257

KEYWORDS: Electroencephalography, Brain activation, Electrodes, Brain mapping, Hemodynamics, Prefrontal cortex, Brain, Statistical analysis, Neuroimaging, Functional magnetic resonance imaging

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Proceedings Article | 1 March 2019 Presentation + Paper

Presentation + Paper

Using fNIRS to identify the brain activation and networks associated with English versus Chinese simultaneous interpreting

Zhen Yuan, Xiaohong Lin

Proceedings Volume 10864, 108640O (2019) https://doi.org/10.1117/12.2508291

KEYWORDS: Brain activation, Brain, Brain mapping, Neuroimaging, Hemodynamics, Sensors, Picosecond phenomena, Statistical analysis, Continuous wave operation, Inspection

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SPIE Journal Paper | 9 June 2018 Open Access

Open Access

Emotion recognition and its relation to prefrontal function and network in heroin plus nicotine dependence: a pilot study

Hada Fong-ha Ieong, Zhen Yuan

NPh, Vol. 5, Issue 02, 025011, (June 2018) https://doi.org/10.1117/12.10.1117/1.NPh.5.2.025011

KEYWORDS: Neodymium, Control systems, Neuroimaging, Brain, Neurophotonics, Cognition, Picosecond phenomena, Hemodynamics, Prefrontal cortex, Network security

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SPIE Journal Paper | 5 June 2018 Open Access

Open Access

Which is more costly in Chinese to English simultaneous interpreting, “pairing” or “transphrasing”? Evidence from an fNIRS neuroimaging study

Xiaohong Lin, Victoria Lai Cheng Lei, Defeng Li, Zhen Yuan

NPh, Vol. 5, Issue 02, 025010, (June 2018) https://doi.org/10.1117/12.10.1117/1.NPh.5.2.025010

KEYWORDS: Brain activation, Brain, Neuroimaging, Neurophotonics, Hemodynamics, Statistical analysis, Brain mapping, Sensors, Bandpass filters, Lithium

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Proceedings Article | 19 February 2018 Paper

Paper

Novel CuS-based nanoprobes for photoacoustic molecular imaging in the second near-infrared region

Zhen Yuan, Duyang Gao

Proceedings Volume 10494, 1049461 (2018) https://doi.org/10.1117/12.2286779

KEYWORDS: Copper, Nanoprobes, Nanostructures, In vivo imaging, Magnetic resonance imaging, Tumors, Gadolinium, Absorption, Photoacoustic spectroscopy, Magnesium

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Proceedings Article | 19 February 2018 Paper

Paper

Semiconducting polymer dot as a highly effective contrast agent for photoacoustic imaging

Zhen Yuan, Jian Zhang

Proceedings Volume 10494, 104944F (2018) https://doi.org/10.1117/12.2286796

KEYWORDS: Polymers, In vivo imaging, Absorption, Nanoparticles, Tissues, Photoacoustic imaging, Semiconductors, Pulsed laser operation, Magnesium, Ultrasonography

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Proceedings Article | 19 February 2018 Paper

Paper

Multi-spectral photoacoustic elasticity tomography

Zhen Yuan, Yubin Liu

Proceedings Volume 10494, 1049437 (2018) https://doi.org/10.1117/12.2286797

KEYWORDS: In vitro testing, Chromophores, Tissues, Acquisition tracking and pointing, Acoustics, Photoacoustic spectroscopy, Photoacoustic tomography, Tomography, Computer simulations, Chemical elements

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Proceedings Article | 13 February 2018 Presentation + Paper

Presentation + Paper

Monitoring of injury induced brain regeneration of the adult zebrafish by using optical coherence tomography

Zhen Yuan, Jian Zhang

Proceedings Volume 10493, 104930I (2018) https://doi.org/10.1117/12.2286798

KEYWORDS: Brain, Neuroimaging, Traumatic brain injury, Tissues, Imaging systems, Skull, Injuries, 3D image processing, Optical coherence tomography, 3D modeling

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Proceedings Article | 8 February 2018 Paper

Paper

Optical mapping of brain activation in gambling disorders

Zhen Yuan, Xiaohong Lin

Proceedings Volume 10480, 1048008 (2018) https://doi.org/10.1117/12.2286778

KEYWORDS: Brain, Brain activation, Hemodynamics, Brain mapping, Sensors, Solids, Neuroimaging, Control systems, Prefrontal cortex, Functional magnetic resonance imaging

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Proceedings Article | 8 February 2018 Paper

Paper

Optical mapping of the brain activity in children with Down's syndrome

Zhen Yuan, Fengmei Lu

Proceedings Volume 10480, 1048009 (2018) https://doi.org/10.1117/12.2286795

KEYWORDS: Brain, Brain mapping, Hemodynamics, Microsoft Foundation Class Library, Heart, Sensors, Cortical activation, Mouth, Data processing, Linear filtering

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Proceedings Article | 31 October 2016 Paper

Paper

Polymer dots with broadband optical absorption (500 nm - 700 nm) and high-efficiency photoacoustic conversion for in vivo multispectral photoacoustic imaging

Jian Zhang, Zhen Yuan

Proceedings Volume 10024, 100242A (2016) https://doi.org/10.1117/12.2245654

KEYWORDS: Photoacoustic imaging, Photoacoustic spectroscopy, In vivo imaging, Polymers, Absorption, Tissue optics, Ultrasonography, Tissues, Magnesium, Microscopy

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Proceedings Article | 9 March 2016 Paper

Paper

Hemodynamic responses can modulate the brain oscillations in low frequency

Zhen Yuan, Feng-Mei Lu, Yi-Feng Wang

Proceedings Volume 9690, 96901U (2016) https://doi.org/10.1117/12.2211237

KEYWORDS: Brain, Near infrared spectroscopy, Cerebral blood flow, Functional magnetic resonance imaging, Positron emission tomography, Hemodynamics, Modulation, Blood, Shape memory alloys, Prefrontal cortex, Health sciences, Synthetic aperture radar, Sensors, Life sciences, Neurophotonics, Optogenetics

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Proceedings Article | 9 March 2016 Paper

Paper

The hemodynamic changes in the human prefrontal cortex during the Flanker and Simon tasks: a fNIRS study

Xiaohong Lin, Zhen Yuan

Proceedings Volume 9690, 96901V (2016) https://doi.org/10.1117/12.2211243

KEYWORDS: Prefrontal cortex, Hemodynamics, Brain, Near infrared spectroscopy, Neuroimaging, Optical tomography, Sensors, Health sciences, Independent component analysis, Brain activation, Control systems

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Proceedings Article | 24 March 2014 Paper

Paper

Combining ICA and Granger causality: a novel tool for investigation of brain dynamics and brain oscillations using fNIRS measurements

Zhen Yuan

Proceedings Volume 8928, 89280I (2014) https://doi.org/10.1117/12.2033212

KEYWORDS: Brain, Independent component analysis, Brain mapping, Time-frequency analysis, Signal processing, Shape memory alloys, Cortical activation, Network security, Chromophores, Brain activation

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Proceedings Article | 3 March 2014 Paper

Paper

Listen to photon propagation in biological tissues: quantitative optical scattering imaging and high-resolution diffuse optical tomography using photoacoustic measurements

Zhen Yuan

Proceedings Volume 8943, 89433Q (2014) https://doi.org/10.1117/12.2033219

KEYWORDS: Scattering, Absorption, Tissue optics, Acquisition tracking and pointing, Biomedical optics, Tissues, Acoustics, Image restoration, Reconstruction algorithms, Soft tissue optics

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Proceedings Article | 17 February 2014 Paper

Paper

A parallel framework for simultaneous FNIRS/FMRI fusion

Zhen Yuan

Proceedings Volume 8937, 89370D (2014) https://doi.org/10.1117/12.2033216

KEYWORDS: Functional magnetic resonance imaging, Independent component analysis, Hemodynamics, Signal processing, Brain, Neuroimaging, Temporal resolution, Blood, Data modeling, Toxic industrial chemicals

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SPIE Journal Paper | 22 October 2013 Open Access

Open Access

Spatiotemporal and time-frequency analysis of functional near infrared spectroscopy brain signals using independent component analysis

Zhen Yuan

JBO, Vol. 18, Issue 10, 106011, (October 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.10.106011

KEYWORDS: Independent component analysis, Brain, Time-frequency analysis, Functional near infrared spectroscopy, Signal processing, Chromophores, Principal component analysis, Functional magnetic resonance imaging, Neuroimaging, Brain mapping

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Proceedings Article | 18 February 2011 Paper

Paper

Image-guided photoacoustic spectroscopy in diagnosis of osteoarthritis in hands: an initial study

J. Xiao, Jishan He, Yao Sun, Huabei Jiang, Zhen Yuan, Eric Sobel

Proceedings Volume 7883, 78834N (2011) https://doi.org/10.1117/12.879439

KEYWORDS: Cartilage, Acoustics, Bone, Tissues, Photoacoustic spectroscopy, Tissue optics, Oxygen, Ultrasonography, Magnetic resonance imaging, Photoacoustic tomography

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Proceedings Article | 3 March 2010 Paper

Paper

Imaging osteoarthritis in the knee joints using x-ray guided diffuse optical tomography

Qizhi Zhang, Zhen Yuan, Eric Sobel, Huabei Jiang

Proceedings Volume 7548, 75484J (2010) https://doi.org/10.1117/12.853402

KEYWORDS: Bone, X-rays, X-ray imaging, Tissues, X-ray optics, 3D image reconstruction, Interfaces, Diffuse optical tomography, Optical properties, Diffuse optical imaging

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SPIE Journal Paper | 1 September 2009 Open Access

Open Access

Comparison of diffusion approximation and higher order diffusion equations for optical tomography of osteoarthritis

Zhen Yuan, Qizhi Zhang, Eric Sobel, Huabei Jiang

JBO, Vol. 14, Issue 05, 054013, (September 2009) https://doi.org/10.1117/12.10.1117/1.3233655

KEYWORDS: Diffusion, X-rays, Scattering, Tissues, Absorption, 3D modeling, Bone, Optical properties, Optical tomography, X-ray imaging

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Proceedings Article | 19 February 2009 Paper

Paper

Three-dimensional diffuse optical tomography of osteoarthritis: a study of 38 finger joints

Eric Sobel, Huabei Jiang, Zhen Yuan, Qizhi Zhang

Proceedings Volume 7166, 71660K (2009) https://doi.org/10.1117/12.809495

KEYWORDS: Absorption, Bone, Cartilage, Diffuse optical tomography, X-rays, Imaging systems, Optical properties, X-ray imaging, Interfaces, Scattering

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Proceedings Article | 19 February 2009 Paper

Paper

Tomographic x-ray guided three-dimensional diffuse optical imaging of osteoarthritis in the finger joints: a clinical study

Huizhu Jiang, Zhen Yuan, Qizhi Zhang, Eric Sobel, Huabei Jiang

Proceedings Volume 7166, 71660G (2009) https://doi.org/10.1117/12.809466

KEYWORDS: X-rays, Tissues, X-ray imaging, X-ray optics, Absorption, Scattering, Tissue optics, Diffuse optical imaging, Reconstruction algorithms, Imaging systems

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Proceedings Article | 12 February 2009 Paper

Paper

Three-dimensional diffuse optical tomography of the whole finger: a step toward full hand imaging

Qizhi Zhang, Zhen Yuan, Yiyong Tan, Eric Sobel, Huabei Jiang

Proceedings Volume 7174, 71740F (2009) https://doi.org/10.1117/12.809760

KEYWORDS: Imaging systems, Bone, Image restoration, Absorption, Scattering, X-ray imaging, X-rays, 3D image processing, CCD cameras, Diffuse optical tomography

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Proceedings Article | 12 February 2009 Paper

Paper

Simultaneous recovery of chromophore concentrations and ultrasound velocity by spectrally resolved photoacoustic tomography

Huabei Jiang, Qizhi Zhang, Zhen Yuan, Stephen Grobmyer

Proceedings Volume 7177, 71770Y (2009) https://doi.org/10.1117/12.809499

KEYWORDS: Acoustics, Acquisition tracking and pointing, Chromophores, Ultrasonography, Image restoration, Photoacoustic spectroscopy, Image processing, Photoacoustic tomography, Reconstruction algorithms, Tissue optics

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Proceedings Article | 12 February 2009 Paper

Paper

Three-dimensional diffuse optical imaging of finger joints based on simplified spherical harmonics approximated-radiative transport model

Eric Sobel, Huabei Jiang, Qizhi Zhang, Zhen Yuan

Proceedings Volume 7174, 71742D (2009) https://doi.org/10.1117/12.809577

KEYWORDS: Reconstruction algorithms, Absorption, 3D modeling, Scattering, Bone, 3D image processing, Diffusion, Cartilage, Spherical lenses, In vivo imaging

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Proceedings Article | 12 February 2009 Paper

Paper

Image-guided optical spectroscopy in diagnosis of osteoarthritis by combining spectral and spatial a priori information

Qizhi Zhang, Huizhu Jiang, Huabei Jiang, Zhen Yuan, Eric Sobel

Proceedings Volume 7174, 71740K (2009) https://doi.org/10.1117/12.809556

KEYWORDS: X-rays, Tissues, X-ray imaging, Bone, Imaging systems, Reconstruction algorithms, Oxygen, Interfaces, Chromophores, Imaging spectroscopy

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SPIE Journal Paper | 1 July 2008 Open Access

Open Access

Tomographic x-ray–guided three-dimensional diffuse optical tomography of osteoarthritis in the finger joints

Zhen Yuan, Qizhi Zhang, Eric Sobel, Huabei Jiang

JBO, Vol. 13, Issue 04, 044006, (July 2008) https://doi.org/10.1117/12.10.1117/1.2965547

KEYWORDS: X-rays, X-ray imaging, Tissues, Scattering, Bone, Absorption, Reconstruction algorithms, X-ray optics, Cartilage, Tomography

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SPIE Journal Paper | 1 May 2007 Open Access

Open Access

Three-dimensional diffuse optical tomography of osteoarthritis: initial results in the finger joints

Zhen Yuan, Qizhi Zhang, Eric Sobel, Huabei Jiang

JBO, Vol. 12, Issue 03, 034001, (May 2007) https://doi.org/10.1117/12.10.1117/1.2737420

KEYWORDS: Cartilage, Absorption, X-rays, Scattering, Bone, X-ray imaging, Diffuse optical tomography, Optical properties, Tissues, 3D image processing

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Proceedings Article | 13 February 2007 Paper

Paper

Three-dimensional finite element-based photoacoustic tomography: initial results

Zhen Yuan, Huabei Jiang

Proceedings Volume 6437, 64371A (2007) https://doi.org/10.1117/12.697068

KEYWORDS: Acoustics, Reconstruction algorithms, 3D modeling, 3D image processing, Photoacoustic tomography, Algorithm development, Chemical elements, Photoacoustic spectroscopy, Detection and tracking algorithms, Biomedical optics

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Proceedings Article | 13 February 2007 Paper

Paper

Simultaneous reconstruction of acoustic and optical properties of heterogeneous tissues by quantitative photoacoustic tomography

Qizhi Zhang, Zhen Yuan, Huabei Jiang, Yao Sun

Proceedings Volume 6437, 64371V (2007) https://doi.org/10.1117/12.697071

KEYWORDS: Acoustics, Tissue optics, Reconstruction algorithms, Tissues, Photoacoustic tomography, Optical properties, Acquisition tracking and pointing, Optical scanning systems, Chemical elements, Absorption

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Proceedings Article | 13 February 2007 Paper

Paper

Quantitative photoacoustic tomography: recovery of optical absorption coefficient maps of heterogeneous media

Zhen Yuan, Qizhi Zhang, Qiang Wang, Huabei Jiang, Lu Yin

Proceedings Volume 6437, 64371S (2007) https://doi.org/10.1117/12.697079

KEYWORDS: Absorption, Tissue optics, Acoustics, Photoacoustic tomography, Acquisition tracking and pointing, Reconstruction algorithms, Diffusion, Photoacoustic spectroscopy, Tissues, Chemical elements

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Proceedings Article | 8 February 2007 Paper

Paper

X-ray guided three-dimensional diffuse optical tomography: in vivo study of osteoarthritis in the finger joints

Zhen Yuan, Eric Sobel, Qizhi Zhang, Huabei Jiang

Proceedings Volume 6431, 643112 (2007) https://doi.org/10.1117/12.701600

KEYWORDS: X-rays, X-ray imaging, Imaging systems, Bone, Cartilage, 3D image processing, Tissues, Absorption, Scattering, X-ray optics

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Proceedings Article | 22 January 2007 Paper

Paper

Numerical simulation of transient nonlinear behaviors of electric-sensitive hydrogel membrane under an external electric field

Lu Yin, Huabei Jiang, Zhen Yuan

Proceedings Volume 6465, 64650W (2007) https://doi.org/10.1117/12.697085

KEYWORDS: Mathematical modeling, Interfaces, Polymers, Numerical simulations, Ions, Chlorine, Sodium, Computer simulations, BioMEMS, Solids

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Showing 5 of 41 publications

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