Dr. Zhonglie Piao Profile

Dr. Zhonglie Piao

Research Fellow at Harvard Medical School

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Publications (11)

Proceedings Article | 5 March 2021 Presentation

Development of a clinical intravascular dual-modality optical coherence tomography and near-infrared autofluorescence/fluorescence imaging platform

Osman Ahsen, Zhonglie Piao, Aditya Kumar, Ara Bablouzian, Jia Liu, Mason Schellenberg, Paola Leon Alarcon, Andreas Wartak, Matthew Beatty, Benjamin Child, Adam Mauskapf, Mazen Albaghdadi, Ryutaro Ikegami, Sarah Giddings, Joseph Gardecki, Victoria Mathieu, Farouc Jaffer, Guillermo Tearney

Proceedings Volume 11621, 116210O (2021) https://doi.org/10.1117/12.2577841

KEYWORDS: Optical coherence tomography, Luminescence, Imaging systems, Tissues, Process control, Near infrared, Visualization, Standards development, Lens design, Control systems

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Proceedings Article | 13 March 2019 Presentation

Multidimensional structures of intrinsically controlled complex laser pulses (Conference Presentation)

Tiancheng Huo, Li Qi, Yusi Miao, Zhonglie Piao, Buyun Zhang, Yan Li, Zhongping Chen

Proceedings Volume 10897, 108971K (2019) https://doi.org/10.1117/12.2510800

KEYWORDS: Fiber lasers, Pulsed laser operation, Polarization, Multimode fibers, Femtosecond phenomena, Electroluminescent displays, 3D metrology, Interferometers, Paraxial approximations, Light wave propagation

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Laser pulses in either laboratory or industry are typically complex objects. Unlike the classical electro-magnetic wave with uniform polarization distribution along the flat wave-front or a general vector beam under the paraxial approximation, the real light pulses, such as the pulses from the high power multimode fiber laser and the dechirped femtosecond pulses with structured wave-front, spectrum and polarization distributions, usually have non-vanishing component in the propagation direction. Therefore, the description of a general vectorial laser pulse should be implemented in multi-dimensional way, for the light is the combination of a three-dimensional(3D) vector field (electric ﬁeld E) and a 3D pseudovector field (magnetic ﬁeld B) in the 3D Euclidean space (R3). Here we report on a novel technique for the multi-dimensional characterization which includes the spatiotemporal amplitude and phase information as well as the vectorial features in 3D Euclidean space of the complex laser pulses, such as the intrinsically controlled femtosecond pulses with higher-order Poincaré sphere beams and vectoral spherical beams. A two-steps-based polarization-sensitive Mach–Zehnder interferometer temporal scan technique was used, at the first time, to capture the complete information of the pulses. The corresponding measurement device, placed on the collimated and attenuated beam at the laser output is consists of a special Mach–Zehnder interferometer, a polarizing beam-splitter and charge-coupled device (CCD) cameras. The reference beam with vertical and horizontal polarization is exported from the cavity and attenuated to a suitable intensity by using a neutral-density filter. After 3D phase unwrapping, removal of the reference curvature, correction of achromatic wave-front distortions, spectral phase and amplitude reconstructions, as well as the measurement for the intrinsic phase of the reference pulse, the complete information of the pulse, include the phase information of the three electronic components, will be obtained. This new measurement capability opens the way to in-depth characterizations and optimizations of the complex laser pulses and ultimately to the study of new phenomena of multimode fiber laser generated laser pulse as well as the interactions between materials and structured ultra-short laser beams.

Proceedings Article | 7 March 2019 Presentation

High-resolution micro-OCT for endothelial cell visualization in the coronary arteries (Conference Presentation)

Kensuke Nishimiya, Osman Ahsen, Biwei Yin, Zhonglie Piao, Jiheun Ryu, Hany Osman, Gargi Sharma, Hui Min Leung, Chia-Pin Liang, Joseph Gardecki, Guillermo Tearney

Proceedings Volume 10855, 1085502 (2019) https://doi.org/10.1117/12.2506264

KEYWORDS: Arteries, Visualization, Image segmentation, Scanning electron microscopy, Image resolution, Imaging technologies, Coherence (optics), Tomography, 3D image processing, Image processing

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Proceedings Article | 14 March 2018 Presentation

Femtosecond laser with intracavity controlled higher-order Poincaré sphere beams and total E-field reconstruction of the pulses (Conference Presentation)

Tiancheng Huo, Li Qi, Yusi Miao, Zhonglie Piao, Buyun Zhang, Jiang Zhu, Yan Li, Zhongping Chen

Proceedings Volume 10549, 105490G (2018) https://doi.org/10.1117/12.2289365

KEYWORDS: Femtosecond phenomena, Polarization, Poincaré sphere, Interferometers, Mode locking, Optical filters, Superposition, Light sources, Fiber lasers, Diffraction gratings

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Light carries both spin and orbital angular momentum and the superpositions of these two dynamical properties have found many applications. Many techniques exist to create such light sources but none allow their creation at the femtosecond laser. Here we report on a novel mode-locked ytterbium-doped fiber laser that generates femtosecond pulses with higher-order Poincaré sphere beams. The controlled generation of such pulses such as azimuthally and radially polarized light with definite orbital angular momentum modes are demonstrated. A unidirectional ring cavity constructed with the Yb-doped fiber placed at the end of the fiber section to reduces unnecessary nonlinear effects is employed for self-starting operation. Two pairs of diffraction gratings are used for compensating the normal group velocity dispersion of the fiber and other elements. Mode-locked operation is achieved based on nonlinear polarization evolution, which is mainly implemented with the single mode fiber, the bulk wave plates and the variable spiral plates (q-plate with topological charge q=0.5). The conversion from spin angular momentum to the OAM and reverse inside the laser cavity are realized by means of a quarter-wave plate and a q-plate so that the polarization control was mapped to OAM mode control. To demonstrate the total spatiotemporal and vectoral characterization of the new type femtosecond laser beams, here, a polarization-sensitive Mach–Zehnder interferometer temporal scan technique was used, at the first time, to capture the complete information of the pulse. The corresponding measurement device, placed on the collimated and attenuated beam at the laser output and simply consists of a special Mach–Zehnder interferometer, a polarizing beam-splitter and two charge-coupled device (CCD) cameras. The reference beam with vertical polarization is exported from the cavity and attenuated to a suitable intensity by using a neutral-density filter. After Fourier filtering, removal of the reference curvature, correction of achromatic wave-front distortions, spectral phase and amplitude reconstructions, as well as the measurement for the intrinsic phase of the reference pulse, the complete information of the pulse will be obtained. This new measurement capability opens the way to in-depth characterization and optimization of the vector vortex femtosecond laser pulse and ultimately to the detection of new phenomena of the interactions between materials and structured femtosecond laser beams in space–time and polarization.

Proceedings Article | 14 March 2018 Presentation

Cellular-resolution, extended depth of focus optical coherence tomography catheter toward in vivo cardiovascular imaging (Conference Presentation)

Biwei Yin, Zhonglie Piao, Chulho Daryl Hyun, Kensuke Nishimiya, Joseph Gardecki, Guillermo Tearney

Proceedings Volume 10471, 104710B (2018) https://doi.org/10.1117/12.2288747

KEYWORDS: Optical coherence tomography, In vivo imaging, Arteries, Gaussian beams, Cardiovascular magnetic resonance imaging, Wavefronts, Endoscopy, Fiber optics, Visualization, Image resolution

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Proceedings Article | 28 April 2016 Presentation

High speed photoacoustic imaging with fast OPO laser at 1.7 μm (Conference Presentation)

Zhonglie Piao, Ma Teng, Jiawen Li, Yueqiao Qu, Mingyue Yu, K. Kirk Shung, Qifa Zhou, Chang-Seok Kim, Zhongping Chen

Proceedings Volume 9708, 97082T (2016) https://doi.org/10.1117/12.2214074

KEYWORDS: Photoacoustic imaging, Optical parametric oscillators, Photoacoustic spectroscopy, Arteries, Gradient-index optics, Medical laser equipment, Ultrasonography, Blood, Absorption, In vivo imaging

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Proceedings Article | 27 April 2016 Presentation

Miniature probe for mechanical properties of vascular lesions using acoustic radiation force optical coherence elastography (Conference Presentation)

Yueqiao Qu, Teng Ma, Youmin He, Mingyue Yu, Rui Li, Jiang Zhu, Cuixia Dai, Zhonglie Piao, K. Kirk Shung, Qifa Zhou, Zhongping Chen

Proceedings Volume 9710, 97100L (2016) https://doi.org/10.1117/12.2208390

KEYWORDS: Tissue optics, Elastography, Acoustics, Coherence (optics), Optical coherence tomography, Tissues, Transducers, Ultrasonics, Doppler tomography, Confocal microscopy

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Proceedings Article | 27 April 2016 Presentation

High speed intravascular photoacoustic imaging of atherosclerotic arteries (Conference Presentation)

Zhonglie Piao, Teng Ma, Yueqiao Qu, Jiawen Li, Mingyue Yu, Youmin He, K. Kirk Shung, Qifa Zhou, Chang-Seok Kim, Zhongping Chen

Proceedings Volume 9689, 968930 (2016) https://doi.org/10.1117/12.2214068

KEYWORDS: Arteries, Photoacoustic imaging, Photoacoustic spectroscopy, Imaging systems, Medical laser equipment, Optical parametric oscillators, Laser optics, Multimode fibers, Ultrasonography, Transducers

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Proceedings Article | 15 March 2016 Paper

A practical optical-resolution photoacoustic microscopy prototype using a 300 mW visible laser diode

Lvming Zeng, Zhonglie Piao, Shenghai Huang, Wangcun Jia, Zhongping Chen

Proceedings Volume 9708, 97084T (2016) https://doi.org/10.1117/12.2209201

KEYWORDS: Semiconductor lasers, Photoacoustic microscopy, Laser optics, Optical fibers, Biomedical optics, Objectives, Signal detection, Imaging systems, In vivo imaging

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Proceedings Article | 8 March 2016 Paper

Automatic three-dimensional segmentation combined with in vivo microvascular network imaging of human retina by intensity-based Doppler variance optical coherence tomography

Zhonglie Piao, Shenghai Huang, Li Qi, Jiang Zhu, Fan Lu, Zhongping Chen

Proceedings Volume 9697, 96973A (2016) https://doi.org/10.1117/12.2214840

KEYWORDS: Image segmentation, 3D image processing, Optical coherence tomography, Retina, Doppler tomography, Computer programming, In vivo imaging, Visualization, Retinal scanning, Angiography, Eye

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SPIE Journal Paper | 13 July 2015 Open Access

In vivo microvascular network imaging of the human retina combined with an automatic three-dimensional segmentation method

Shenghai Huang, Zhonglie Piao, Jiang Zhu, Fan Lu, Zhongping Chen

JBO, Vol. 20, Issue 07, 076003, (July 2015) https://doi.org/10.1117/12.10.1117/1.JBO.20.7.076003

KEYWORDS: Image segmentation, Retina, 3D image processing, Optical coherence tomography, In vivo imaging, Computer programming, Visualization, Doppler tomography, Video, Angiography

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