A whole brain atlas with sub-parcellation of cortical gyri using resting fMRI

Anand A. Joshi; Soyoung Choi; Gaurav Sonkar; Minqi Chong; Jorge Gonzalez-Martinez; Dileep Nair; David W. Shattuck; Hanna Damasio; Richard M. Leahy

doi:10.1117/12.2254681

2 March 2017 A whole brain atlas with sub-parcellation of cortical gyri using resting fMRI

Anand A. Joshi, Soyoung Choi, Gaurav Sonkar, Minqi Chong, Jorge Gonzalez-Martinez, Dileep Nair, David W. Shattuck, Hanna Damasio, Richard M. Leahy

Author Affiliations +

Proceedings Volume 10133, Medical Imaging 2017: Image Processing; 101330O (2017) https://doi.org/10.1117/12.2254681
Event: SPIE Medical Imaging, 2017, Orlando, Florida, United States

Abstract

The new hybrid-BCI-DNI atlas is a high-resolution MPRAGE, single-subject atlas, constructed using both anatomical and functional information to guide the parcellation of the cerebral cortex. Anatomical labeling was performed manually on coronal single-slice images guided by sulcal and gyral landmarks to generate the original (non-hybrid) BCI-DNI atlas. Functional sub-parcellations of the gyral ROIs were then generated from 40 minimally preprocessed resting fMRI datasets from the HCP database. Gyral ROIs were transferred from the BCI-DNI atlas to the 40 subjects using the HCP grayordinate space as a reference. For each subject, each gyral ROI was subdivided using the fMRI data by applying spectral clustering to a similarity matrix computed from the fMRI time-series correlations between each vertex pair. The sub-parcellations were then transferred back to the original cortical mesh to create the subparcellated hBCI-DNI atlas with a total of 67 cortical regions per hemisphere. To assess the stability of the gyral subdivisons, a separate set of 60 HCP datasets were processed as follows: 1) coregistration of the structural scans to the hBCI-DNI atlas; 2) coregistration of the anatomical BCI-DNI atlas without functional subdivisions, followed by sub-parcellation of each subject’s resting fMRI data as described above. We then computed consistency between the anatomically-driven delineation of each gyral subdivision and that obtained per subject using individual fMRI data. The gyral sub-parcellations generated by atlas-based registration show variable but generally good overlap of the confidence intervals with the resting fMRI-based subdivisions. These consistency measures will provide a quantitative measure of reliability of each subdivision to users of the atlas.

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Anand A. Joshi, Soyoung Choi, Gaurav Sonkar, Minqi Chong, Jorge Gonzalez-Martinez, Dileep Nair, David W. Shattuck, Hanna Damasio, and Richard M. Leahy "A whole brain atlas with sub-parcellation of cortical gyri using resting fMRI", Proc. SPIE 10133, Medical Imaging 2017: Image Processing, 101330O (2 March 2017); https://doi.org/10.1117/12.2254681

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