Hyperspectral near infrared spectroscopy assessment of the brain during hypoperfusion

Thu N. Nguyen; Wen Wu; Ermias Woldemichael; Vladislav Toronov; Steve Lin

doi:10.1117/12.2288794

12 February 2018 Hyperspectral near infrared spectroscopy assessment of the brain during hypoperfusion

Thu N. Nguyen, Wen Wu, Ermias Woldemichael, Vladislav Toronov, Steve Lin

Proceedings Volume 10484, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVI; 1048419 (2018) https://doi.org/10.1117/12.2288794
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

Two-thirds of out-of-hospital cardiac arrest patients, who survive to hospital admission, die in the hospital from neurological injuries related to cerebral hypoperfusion. Hyperspectral near infrared spectroscopy (hNIRS) is a noninvasive technique that measures the major chromophores in the brain, such as oxygenated hemoglobin, deoxygenated hemoglobin and cytochrome C oxidase ([CCO]), an intracellular marker of oxygen consumption. We have demonstrated that hNIRS is feasible and can detect changes in cerebral oxygenation and metabolism in patients undergoing transcatheter aortic valve insertion (TAVI) – a procedure that temporarily induces sudden hypotension and hypoperfusion that mimics cardiac arrest. Using multi-distance hNIRS, we found that while measured regional oxygen saturation (rSO2) changes resulted mainly from the extra-cerebral tissues, [CCO] changes during cardiac arrests occurred mainly in the brains of patients. We also applied the hNIRS algorithm based on the “2-layer model” to the data to measure cerebral oxygen saturation and [CCO] in patients during the procedure.

Citation Download Citation

Thu N. Nguyen, Wen Wu, Ermias Woldemichael, Vladislav Toronov, and Steve Lin "Hyperspectral near infrared spectroscopy assessment of the brain during hypoperfusion", Proc. SPIE 10484, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVI, 1048419 (12 February 2018); https://doi.org/10.1117/12.2288794

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
8 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Near infrared spectroscopy

Brain

Tissues

Oxygen

Data modeling

Chromophores

Skull

Show All Keywords

Keywords/Phrases

Search In:

Publication Years