Label-free detection of the carcinoembryonic antibody protein based MoS2 nanosheets using terahertz spectroscopy

Xingxing Lu; Pengfei Xie; Yiwen Sun

doi:10.1117/12.2500373

9 November 2018 Label-free detection of the carcinoembryonic antibody protein based MoS2 nanosheets using terahertz spectroscopy

Xingxing Lu, Pengfei Xie, Yiwen Sun

Author Affiliations +

Proceedings Volume 10826, Infrared, Millimeter-Wave, and Terahertz Technologies V; 1082607 (2018) https://doi.org/10.1117/12.2500373
Event: SPIE/COS Photonics Asia, 2018, Beijing, China

Abstract

As a new two-dimensional material, MoS₂ has been extensively studied in terahertz modulation due to its excellent photoelectric properties. Herein, we studied a novel method for label-free detection of the carcinoembryonic antibody based on MoS₂ nanosheets using terahertz spectroscopy. Protein molecules were fabricated on the COC substrates with MoS₂ nanosheets. A self-made simple sample cell was used to get signal of protein molecules in a liquid phase. Computational analysis was performed using a classic sandwich structure model. The refractive index and absorption coefficient were calculated. As a result, the THz signal increased with the protein concentration increasing in 0.2-1.1THz. The cole-cole plot was also investigated. The effectiveness of MoS₂ nanosheets for adsorbing protein molecules has been demonstrated, which can be used to detect carcinoembryonic antigen sensitively in the future.

Citation Download Citation

Xingxing Lu, Pengfei Xie, and Yiwen Sun "Label-free detection of the carcinoembryonic antibody protein based MoS2 nanosheets using terahertz spectroscopy", Proc. SPIE 10826, Infrared, Millimeter-Wave, and Terahertz Technologies V, 1082607 (9 November 2018); https://doi.org/10.1117/12.2500373

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