Quantitative analysis of choriocapillaris in non-human primates using swept-source optical coherence tomography angiography (SS-OCTA) (Conference Presentation)

Bingyao Tan; Jacqueline Chua; Amutha Barathi Veluchamy; Baskaran Mani; Anita Chan; Leopold Schmetterer

doi:10.1117/12.2508708

13 March 2019 Quantitative analysis of choriocapillaris in non-human primates using swept-source optical coherence tomography angiography (SS-OCTA) (Conference Presentation)

Bingyao Tan, Jacqueline Chua, Amutha Barathi Veluchamy, Baskaran Mani, Anita Chan, Leopold Schmetterer

Author Affiliations +

Proceedings Volume 10858, Ophthalmic Technologies XXIX; 108580Q (2019) https://doi.org/10.1117/12.2508708
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Choriocapillaris is a unique vascular plexus located posterior to the retinal pigment epithelium. In the recent years, there is an increasing interest to investigate choriocapillaris alteration and progression of eye diseases and aging, using the optical coherence tomography angiography (OCTA). However, standardized algorithm for analysis has not been developed. Herein, we present non-invasive, in-vivo, high-resolution images of the non-human primates’ choriocapillaris using OCTA. Images were acquired with a prototype swept-source OCTA (SS-OCTA) system with 100kHz A-scan/s rate, over regions of 3×3 mm2 and 12×12 mm2. The non-perfusion area, also called flow voids, were segmented with an intensity damped, illuminance-compensated algorithm. The optimized quantification of the choriocapillaris flow voids may have applications in a wide array of eye diseases including age-related macular degeneration (AMD) and visualization of choriocapillaris in animal models could aid future studies on choroid involvement in models of eye disease.

Conference Presentation

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Bingyao Tan, Jacqueline Chua, Amutha Barathi Veluchamy, Baskaran Mani, Anita Chan, and Leopold Schmetterer "Quantitative analysis of choriocapillaris in non-human primates using swept-source optical coherence tomography angiography (SS-OCTA) (Conference Presentation)", Proc. SPIE 10858, Ophthalmic Technologies XXIX, 108580Q (13 March 2019); https://doi.org/10.1117/12.2508708

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