Interrogation of photonic biosensors using optical frequency combs

Markus Knoerzer; Crispin Szydzik; Guanghui Ren; Cesar S. Huertas; Sonya Palmer; Phuong Tang; Thach G. Nguyen; Lam Bui; Andreas Boes; Arnan Mitchell

doi:10.1117/12.2541248

30 December 2019 Interrogation of photonic biosensors using optical frequency combs

Markus Knoerzer, Crispin Szydzik, Guanghui Ren, Cesar S. Huertas, Sonya Palmer, Phuong Tang, Thach G. Nguyen, Lam Bui, Andreas Boes, Arnan Mitchell

Author Affiliations +

Proceedings Volume 11202, Biophotonics Australasia 2019; 112020B (2019) https://doi.org/10.1117/12.2541248
Event: ANZCOP, 2019, Melbourne, Australia

Abstract

In this contribution, we show how the stability and ease-of-use of an integrated interferometric photonic biosensor platform can be enhanced using optical frequency combs, without any necessary changes to the sensor chip design. We show that if the comb line spacing of the optical frequency comb is adjusted to be at 120° intervals of the periodic spectral response of the used Mach-Zehnder interferometer and the transmission power values of the three comb lines are recorded over time, it is possible to extract the interferometer phase linearly and continuously for every sample point. This measurement approach provides an accurate phase measurement and is independent of the interferometer bias. Furthermore, it is robust against intensity fluctuations which are common to all three used comb lines. Our demonstration uses a simple silicon photonic interferometric refractive index sensor, and we show that the benefits of our approach can be achieved without degrading the lower limit of detection of 3.70×10^-7 RIU of our sensor platform. Our technique can be applied to any interferometric sensor and only requires a single input and single output and does not need any special couplers. This technique offers a drop-in replacement to the commonly used single wavelength phase measurement.

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Markus Knoerzer, Crispin Szydzik, Guanghui Ren, Cesar S. Huertas, Sonya Palmer, Phuong Tang, Thach G. Nguyen, Lam Bui, Andreas Boes, and Arnan Mitchell "Interrogation of photonic biosensors using optical frequency combs", Proc. SPIE 11202, Biophotonics Australasia 2019, 112020B (30 December 2019); https://doi.org/10.1117/12.2541248

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