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10 March 2020 Wide-field dual-probe imaging approach validated using QDs and skin mimicking phantoms (Conference Presentation)
Alexander Saeboe, Keyi Han, Joshua Kays, Reyhaneh Toufanian, Allison Dennis
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Proceedings Volume 11254, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVII; 112540F (2020) https://doi.org/10.1117/12.2546864
Event: SPIE BiOS, 2020, San Francisco, California, United States
Abstract
We utilized these NIR QDs to demonstrate the utility of an image processing algorithm capable of determining the relative concentration ratios of two distinct emitters at various tissue depths. This algorithm is based on the dual probe imaging method, which we modified for use in wide-field imaging systems. The algorithm was validated using skin-mimicking tissue phantoms that were used to vary the effective imaging depth from 0-1.2 mm. The algorithm correctly determined concentration ratios of a two-color QD system for variations in concentration ≥ 10%, independently of depth. These contrast agents and the imaging approach are being adapted for use for in vivo targeted tumor imaging.ng adapted for use for in vivo targeted tumor imaging.
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Alexander Saeboe, Keyi Han, Joshua Kays, Reyhaneh Toufanian, and Allison Dennis "Wide-field dual-probe imaging approach validated using QDs and skin mimicking phantoms (Conference Presentation)", Proc. SPIE 11254, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVII, 112540F (10 March 2020); https://doi.org/10.1117/12.2546864
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KEYWORDS
Skin
Tumors
Imaging systems
Tissues
Image processing
Chemistry
Microscopy
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