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10 March 2020 Magnetically aggregated biosensors for sensitive detection of biomarkers at low concentrations (Conference Presentation)
Shmuel Burg, Meir Cohen, Michael Margulis, Shira Roth, Amos Danielli
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Proceedings Volume 11258, Frontiers in Biological Detection: From Nanosensors to Systems XII; 1125803 (2020) https://doi.org/10.1117/12.2543206
Event: SPIE BiOS, 2020, San Francisco, California, United States
Abstract
Detection of biomarkers at low concentrations is essential for early diagnosis of numerous diseases. In many sensitive assays, the target molecules are tagged using fluorescently labeled probes and captured using magnetic beads. Current devices rely on quantifying the target molecules by detecting the fluorescent signal from individual beads. Here, we propose a compact fluorescence-based magnetically aggregated biosensors (MAB) system. Using the device to detect human Interleukin-8, we demonstrated a 0.1 ng/L limit of detection and a 4-log dynamic range, performance which is on par with the most sensitive devices, but is achieved without their bulk and cost.
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Shmuel Burg, Meir Cohen, Michael Margulis, Shira Roth, and Amos Danielli "Magnetically aggregated biosensors for sensitive detection of biomarkers at low concentrations (Conference Presentation)", Proc. SPIE 11258, Frontiers in Biological Detection: From Nanosensors to Systems XII, 1125803 (10 March 2020); https://doi.org/10.1117/12.2543206
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KEYWORDS
Biosensors
Magnetism
Signal detection
Molecules
Target detection
Luminescence
Molecular aggregates
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