Remote, non-genetic modulation of cellular activity using hybrid-nanomaterials

Tzahi Cohen-Karni

doi:10.1117/12.2568714

22 August 2020 Remote, non-genetic modulation of cellular activity using hybrid-nanomaterials

Tzahi Cohen-Karni

Proceedings Volume 11475, Organic and Hybrid Sensors and Bioelectronics XIII; 114750G (2020) https://doi.org/10.1117/12.2568714
Event: SPIE Organic Photonics + Electronics, 2020, Online Only

Abstract

Photostimulation using Au and Si-based nanomaterials has shown promise for optical stimulation of cells. However, these methods still suffer from key limitations: the need for high laser power, low thermal conversion efficiency, and unproven long-term stability. We report a breakthrough hybrid-nanomaterial for remote and non-genetic light-induced control of targeted cell activity. We combine one-dimensional (1D) nanowires (NWs) and two-dimensional (2D) graphene flakes grown out-of-plane with tailor-made physical properties for highly controlled photostimulation. Photostimulation using NW templated 3D fuzzy graphene (NT-3DFG) is flexible due to its broadband absorption and does not generate cellular stress. Our light-based platform adds a powerful toolset to the basic scientists studying cell signaling within and between tissues.

Conference Presentation

Citation Download Citation

Tzahi Cohen-Karni "Remote, non-genetic modulation of cellular activity using hybrid-nanomaterials", Proc. SPIE 11475, Organic and Hybrid Sensors and Bioelectronics XIII, 114750G (22 August 2020); https://doi.org/10.1117/12.2568714

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