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5 March 2021 In-vivo optical microscopy and single cell transcriptomics approaches provide insights into therapeutic response of vitiligo
Griffin R. Lentsch, Jessica Shiu, Jessica Flesher, Pezhman Mobasher, Christopher Polleys, Craig Mizzoni, Karsten König, Suoqin Jin, Lihua Zhang, Bruce J. Tromberg, Qing Nie, Irene Georgakoudi, Anand K. Ganesan, Mihaela Balu
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Proceedings Volume 11618, Photonics in Dermatology and Plastic Surgery 2021; 116180P (2021) https://doi.org/10.1117/12.2582167
Event: SPIE BiOS, 2021, Online Only
Abstract
Vitiligo is an immune skin disorder consisting of depigmented skin patches caused by the destruction of epidermal melanocytes. Vitiligo treatment represents a clinical challenge since the re-pigmentation mechanism is not fully understood. In this pilot study, we employ in-vivo multiphoton microscopy to evaluate epidermal keratinocyte metabolic state before and during treatment, in-vivo reflectance confocal microscopy to track melanocyte migration after treatment initiation, and single cell transcriptomics to identify unique cell populations more abundant in stable vitiligo lesions compared to normal skin. The findings provide insights into the role of certain cell populations in the viability of micro-grafting treatments.
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© (2021) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
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Griffin R. Lentsch, Jessica Shiu, Jessica Flesher, Pezhman Mobasher, Christopher Polleys, Craig Mizzoni, Karsten König, Suoqin Jin, Lihua Zhang, Bruce J. Tromberg, Qing Nie, Irene Georgakoudi, Anand K. Ganesan, and Mihaela Balu "In-vivo optical microscopy and single cell transcriptomics approaches provide insights into therapeutic response of vitiligo", Proc. SPIE 11618, Photonics in Dermatology and Plastic Surgery 2021, 116180P (5 March 2021); https://doi.org/10.1117/12.2582167
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KEYWORDS
Skin
In vivo imaging
Optical microscopy
Confocal microscopy
Multiphoton microscopy
Quantitative analysis
Reflectivity
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