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5 March 2021 The relation between pre-existing plaque burden and strut coverage after DES implantation in familial hypercholesterolemia swine: an OCT study
Francesca Razzi, Jouke Dijkstra, Karen Witberg, Jurgen Ligthart, Sharad Ramlal, Mathijs Stam, Ilona Krabbendam-Peters, Ayla Hoogendoorn, Dirk-Jan Duncker, Jan van Esch, Jolanda Wentzel, Gijs van Soest, Volkert van Steijn, Evelyn Regar, Heleen van Beusekom
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Proceedings Volume 11621, Diagnostic and Therapeutic Applications of Light in Cardiology 2021; 116210F (2021) https://doi.org/10.1117/12.2582723
Event: SPIE BiOS, 2021, Online Only
Abstract
Neointima (NI) healing after implantation of drug-eluting coronary stents (DES) is often preclinically evaluated in healthy swine coronary models, which only allow limited conclusions. In this study, DES were implanted in an adult familial hypercholesterolemia (FH) swine model in order to better reproduce the range of NI responses that are seen in humans. Serial OCT imaging was performed before and after stenting, and at 28 days FU. The NI response showed a wide spectrum of strut coverage types. Higher percentages baseline plaque burden resulted in more uncovered struts and heterogeneous patterns of strut coverage, uniquely showing similarities to human responses.
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Francesca Razzi, Jouke Dijkstra, Karen Witberg, Jurgen Ligthart, Sharad Ramlal, Mathijs Stam, Ilona Krabbendam-Peters, Ayla Hoogendoorn, Dirk-Jan Duncker, Jan van Esch, Jolanda Wentzel, Gijs van Soest, Volkert van Steijn, Evelyn Regar, and Heleen van Beusekom "The relation between pre-existing plaque burden and strut coverage after DES implantation in familial hypercholesterolemia swine: an OCT study", Proc. SPIE 11621, Diagnostic and Therapeutic Applications of Light in Cardiology 2021, 116210F (5 March 2021); https://doi.org/10.1117/12.2582723
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KEYWORDS
Optical coherence tomography
Safety
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