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5 March 2021 Simulation study of speckle contrast optical tomography performance using an anatomical head model
Inema E. Orukari, Chen-Hao P. Lin, Lisa Kobayashi Frisk, Manish Verma, Sumana Chetia, Adam T. Eggebrecht, Turgut Durduran, Joseph P. Culver, Jason W. Trobaugh
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Proceedings Volume 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics; 116290W (2021) https://doi.org/10.1117/12.2578493
Event: SPIE BiOS, 2021, Online Only
Abstract
High-density speckle contrast optical tomography (HD-SCOT) is attractive for imaging cerebral blood flow (CBF), with desirable cost and signal-to-noise ratio (SNR). Previous studies showed feasibility of HD-SCOT in rodent models using lab instruments. To investigate potential performance for a dedicated HD-SCOT instrument, we simulated HD-SCOT imaging for an anatomical head model. We evaluated potential imaging performance versus depth for varying exposure times and measurement availability. Results showed that an HD-SCOT system could have image resolution of 13 mm full-width-half-maximum at 12 mm depth, with instrument parameters affecting localization error and SNR. These results will guide design of future research instruments
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Inema E. Orukari, Chen-Hao P. Lin, Lisa Kobayashi Frisk, Manish Verma, Sumana Chetia, Adam T. Eggebrecht, Turgut Durduran, Joseph P. Culver, and Jason W. Trobaugh "Simulation study of speckle contrast optical tomography performance using an anatomical head model", Proc. SPIE 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics, 116290W (5 March 2021); https://doi.org/10.1117/12.2578493
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KEYWORDS
Performance modeling
Head
Optical tomography
Speckle
Distance measurement
Instrument modeling
Signal to noise ratio
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