Wearable high-density diffuse optical tomography (WHD-DOT) instrument for mapping human brain activity

Alvin Agato; Edward J. Richter; Calamity Svoboda; Arefeh Sherafati; Broc Burke; Adam T. Eggebrecht; Joseph P. Culver

doi:10.1117/12.2579116

5 March 2021 Wearable high-density diffuse optical tomography (WHD-DOT) instrument for mapping human brain activity

Alvin Agato, Edward J. Richter, Calamity Svoboda, Arefeh Sherafati, Broc Burke, Adam T. Eggebrecht, Joseph P. Culver

Proceedings Volume 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics; 116291T (2021) https://doi.org/10.1117/12.2579116
Event: SPIE BiOS, 2021, Online Only

Abstract

We developed a wearable HD-DOT instrument (WHD-DOT) that provides a safe and portable neuroimaging modality with enhanced image resolution and brain specificity. Our design replaces bulky fibers with smart electronic cylindrical source and detector modules that brush through hair and maintain stable optode-scalp coupling. Our current prototype has four independent WHD patches to create a system with 32 sources and 32 detectors at 13 mm optode spacing. Light level vs. distance curves confirm dynamic range and cross-talk specifications match fiber-based HD-DOT. We tested feasibility using retinotopic mapping of visual cortex. Optode location error between photometric measurements and MRI-based fiducials is <5mm.

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Alvin Agato, Edward J. Richter, Calamity Svoboda, Arefeh Sherafati, Broc Burke, Adam T. Eggebrecht, and Joseph P. Culver "Wearable high-density diffuse optical tomography (WHD-DOT) instrument for mapping human brain activity", Proc. SPIE 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics, 116291T (5 March 2021); https://doi.org/10.1117/12.2579116

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KEYWORDS

Brain

Diffuse optical tomography

Brain mapping

Photometry

Sensors

Neuroimaging

Multichannel imaging systems

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