Automated craniotomy with impedance-sensitive skull curvature profiling

Michelle Hedlund; Hunter Banks; Annie Bice; Shengxuan Chen; Joseph Culver

doi:10.1117/12.2577682

5 March 2021 Automated craniotomy with impedance-sensitive skull curvature profiling

Michelle Hedlund, Hunter Banks, Annie Bice, Shengxuan Chen, Joseph Culver

Proceedings Volume 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics; 116292B (2021) https://doi.org/10.1117/12.2577682
Event: SPIE BiOS, 2021, Online Only

Abstract

Scattering in the skull limits spatial resolution in optical neuroimaging experiments in mice, so it is necessary to excise a portion of the skull. Such craniotomy procedures have traditionally been done manually, but automating the process provides greater control of the cutting path and depth. A computer numerical controlled (CNC) milling machine can perform craniotomies of arbitrary shape and position with high precision. Automating the procedure improves repeatability and consistency, poses fewer risks for damaging the brain, and makes the procedure easier to learn. We have developed an automated craniotomy procedure which utilizes a CNC machine to obtain a curvature profile of the skull with an impedance-sensitive probing circuit and to interpolate a cut path along this profile to remove a portion of a mouse’s skull. This procedure does not damage the underlying brain tissue and can be performed in under two hours.

Conference Presentation

Citation Download Citation

Michelle Hedlund, Hunter Banks, Annie Bice, Shengxuan Chen, and Joseph Culver "Automated craniotomy with impedance-sensitive skull curvature profiling", Proc. SPIE 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics, 116292B (5 March 2021); https://doi.org/10.1117/12.2577682

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available