In vivo microscopic assessment of idiopathic pulmonary fibrosis using endobronchial optical coherence tomography: a prospective diagnostic study

Sreyankar Nandy; Rebecca A. Israel M.D.; Ashok Muniappan M.D.; Angela Shih M.D.; Benjamin W. Roop; Amita Sharma M.D.; Colleen M. Keyes M.D.; Thomas V. Colby M.D.; Hugh G. Auchincloss M.D.; Henning A. Gaissert M.D.; Michael Lanuti M.D.; Christopher R. Morse M.D.; Harald C. Ott M.D.; John C. Wain M.D.; Cameron D. Wright M.D.; Mari Mino-Kenudson M.D.; Nora K. Horick; Lloyd L. Liang; Diane L. Davies; David C. Adams; Margit V. Szabari M.D.; Peter Caravan; Benjamin D. Medoff M.D.; Melissa J. Suter; Lida P. Hariri M.D.

doi:10.1117/12.2581310

5 March 2021 In vivo microscopic assessment of idiopathic pulmonary fibrosis using endobronchial optical coherence tomography: a prospective diagnostic study

Sreyankar Nandy, Rebecca A. Israel M.D., Ashok Muniappan M.D., Angela Shih M.D., Benjamin W. Roop, Amita Sharma M.D., Colleen M. Keyes M.D., Thomas V. Colby M.D., Hugh G. Auchincloss M.D., Henning A. Gaissert M.D., Michael Lanuti M.D., Christopher R. Morse M.D., Harald C. Ott M.D., John C. Wain M.D., Cameron D. Wright M.D., Mari Mino-Kenudson M.D., Nora K. Horick, Lloyd L. Liang, Diane L. Davies, David C. Adams, Margit V. Szabari M.D., Peter Caravan, Benjamin D. Medoff M.D., Melissa J. Suter, Lida P. Hariri M.D.

Author Affiliations +

Proceedings Volume 11630, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV; 116300R (2021) https://doi.org/10.1117/12.2581310
Event: SPIE BiOS, 2021, Online Only

Abstract

Idiopathic pulmonary fibrosis (IPF) is a fatal form of fibrotic interstitial lung disease (ILD). Early diagnosis of IPF is essential, but often requires invasive surgery. We conduct a prospective study evaluating the diagnostic accuracy of endobronchial optical coherence tomography (EB-OCT) for IPF diagnosis as compared to concurrent surgical lung biopsy (SLB) and clinical follow-up diagnosis. EB-OCT was performed immediately prior to SLB in 27 ILD patients. EB-OCT was 100% sensitive and 100% specific for both histologic and clinical follow up diagnosis of IPF. The results demonstrate the potential of EB-OCT as minimally-invasive, low-risk in vivo method for microscopic IPF diagnosis.

Conference Presentation

Citation Download Citation

Sreyankar Nandy, Rebecca A. Israel M.D., Ashok Muniappan M.D., Angela Shih M.D., Benjamin W. Roop, Amita Sharma M.D., Colleen M. Keyes M.D., Thomas V. Colby M.D., Hugh G. Auchincloss M.D., Henning A. Gaissert M.D., Michael Lanuti M.D., Christopher R. Morse M.D., Harald C. Ott M.D., John C. Wain M.D., Cameron D. Wright M.D., Mari Mino-Kenudson M.D., Nora K. Horick, Lloyd L. Liang, Diane L. Davies, David C. Adams, Margit V. Szabari M.D., Peter Caravan, Benjamin D. Medoff M.D., Melissa J. Suter, and Lida P. Hariri M.D. "In vivo microscopic assessment of idiopathic pulmonary fibrosis using endobronchial optical coherence tomography: a prospective diagnostic study", Proc. SPIE 11630, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV, 116300R (5 March 2021); https://doi.org/10.1117/12.2581310

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available