Towards SFDI endoscopy with structured illumination from randomized speckle patterns

Mason T. Chen; Taylor L. Bobrow; Nicholas J. Durr

doi:10.1117/12.2578940

5 March 2021 Towards SFDI endoscopy with structured illumination from randomized speckle patterns

Mason T. Chen, Taylor L. Bobrow, Nicholas J. Durr

Proceedings Volume 11631, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIX; 116310Y (2021) https://doi.org/10.1117/12.2578940
Event: SPIE BiOS, 2021, Online Only

Abstract

Spatial Frequency Domain Imaging (SFDI) is a powerful technique for non-contact tissue optical property and chromophore mapping over a large field of view. However, a major challenge that limits the clinical adoption of SFDI is that it requires carefully-controlled imaging geometry and the projection of known spatial frequencies. We present speckle-illumination SFDI (si-SFDI), a projector-free technique that measures tissue optical properties from structured illumination formed by randomized speckle patterns. We compute the local power spectral density of images under speckle illumination, from which a high-frequency and a low-frequency tissueresponse parameter can be characterized for each pixel. A lookup table generated by Monte-Carlo simulations is subsequently used to accurately determine optical absorption and reduced scattering coefficients. Compared to conventional SFDI, si-SFDI may be particularly useful for endoscopic applications due to its utilization of simple coherent illumination, which makes it more easily incorporated into existing endoscopic systems. Moreover, speckle illumination offers a large depth of focus compared to projector-based illumination. In this study, we explore wide-field optical property mapping with an endoscope camera and fiber-coupled laser speckle illumination. We apply this technique to tissue-mimicking silicone phantoms and biological tissues. The accuracy of si-SFDI is evaluated by comparing to optical properties measured by conventional SFDI. Future work could accelerate si-SFDI reconstruction by using parallel computing or machine learning algorithms.

Conference Presentation

Citation Download Citation

Mason T. Chen, Taylor L. Bobrow, and Nicholas J. Durr "Towards SFDI endoscopy with structured illumination from randomized speckle patterns", Proc. SPIE 11631, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIX, 116310Y (5 March 2021); https://doi.org/10.1117/12.2578940

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available