Optical detection of triple negative breast cancer metabolism

Mira Swartzlander; Pegah Bagheri; Jie Hao; Honghao Zha; Anthony A. Fung; Lingyan Shi

doi:10.1117/12.2585411

5 March 2021 Optical detection of triple negative breast cancer metabolism

Mira Swartzlander, Pegah Bagheri, Jie Hao, Honghao Zha, Anthony A. Fung, Lingyan Shi

Proceedings Volume 11636, Optical Biopsy XIX: Toward Real-Time Spectroscopic Imaging and Diagnosis; 116360L (2021) https://doi.org/10.1117/12.2585411
Event: SPIE BiOS, 2021, Online Only

Abstract

Early diagnosis of Triple Negative Breast Cancer (TNBC) is essential to implementing early, life-saving treatment before the development of metastases. Traditional methods for detecting TNBC is difficult, being both tedious and vulnerable to false positive results. Here we combine optical imaging techniques—deuterium probed resonance Raman spectroscopy (RRS) and multiphoton fluorescence (MPF) to detect TNBC metabolism in early stage. These hallmarks such as glucose and lipid metabolism are revealed through chemical bond vibrational modes with RRS and morphological changes with MPF at subcellular scale.

Conference Presentation

Citation Download Citation

Mira Swartzlander, Pegah Bagheri, Jie Hao, Honghao Zha, Anthony A. Fung, and Lingyan Shi "Optical detection of triple negative breast cancer metabolism", Proc. SPIE 11636, Optical Biopsy XIX: Toward Real-Time Spectroscopic Imaging and Diagnosis, 116360L (5 March 2021); https://doi.org/10.1117/12.2585411

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