3D high-resolution laser printing of monolithic glass suspended microchannel resonators for enhanced biosensing

Andrea Lovera; Roberta Calmo; Alessandro Chiadò; Davide Scaiola; Francesca Bosco; Carlo Ricciardi; Stefano Stassi; Rosanna Toscano

doi:10.1117/12.2578756

5 March 2021 3D high-resolution laser printing of monolithic glass suspended microchannel resonators for enhanced biosensing

Andrea Lovera, Roberta Calmo, Alessandro Chiadò, Davide Scaiola, Francesca Bosco, Carlo Ricciardi, Stefano Stassi, Rosanna Toscano

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Proceedings Volume 11637, Microfluidics, BioMEMS, and Medical Microsystems XIX; 116370J (2021) https://doi.org/10.1117/12.2578756
Event: SPIE BiOS, 2021, Online Only

Abstract

Suspended microchannel resonators (SMRs) are sensitive biosensors for microgravimetric analysis. In this work, an innovative glass SMR was monolithically manufactured by a femtosecond laser technique coupled with a wet etching. The SMR was used to analyze liquids with different density, thanks to a 1.04·10⁻³ kg/m³ density resolution, comparable with the state-of-art silicon-based SMRs. The effective biosensing capability was demonstrated by evaluating the microbial load of different concentrations of P. fluorescens. This innovative and completely transparent SMR can be exploited for real time biosensing, associated with a microscope analysis. Rapid and cost-effective 3D FEMTOPRINT technology can sustain industrial production for point-of-care devices.

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Andrea Lovera, Roberta Calmo, Alessandro Chiadò, Davide Scaiola, Francesca Bosco, Carlo Ricciardi, Stefano Stassi, and Rosanna Toscano "3D high-resolution laser printing of monolithic glass suspended microchannel resonators for enhanced biosensing", Proc. SPIE 11637, Microfluidics, BioMEMS, and Medical Microsystems XIX, 116370J (5 March 2021); https://doi.org/10.1117/12.2578756

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KEYWORDS

Resonators

Glasses

3D printing

Biosensing

Nonimpact printing

Proteins

Resistance

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