In silico experiments of time-resolved near-infrared light transport through human fingers with simulated rheumatoid arthritis

Seva Ioussoufovitch; Mamadou Diop

doi:10.1117/12.2576899

5 March 2021 In silico experiments of time-resolved near-infrared light transport through human fingers with simulated rheumatoid arthritis

Seva Ioussoufovitch, Mamadou Diop

Author Affiliations +

Proceedings Volume 11639, Optical Tomography and Spectroscopy of Tissue XIV; 116390J (2021) https://doi.org/10.1117/12.2576899
Event: SPIE BiOS, 2021, Online Only

Abstract

Diffuse optical techniques have been used to assess joint inflammation in rheumatoid arthritis (RA); however, there is scant data on the use of time-domain (TD) techniques for this purpose. We conducted TD simulations in a realistic finger joint and investigated how TD parameters changed in response to simulated joint inflammation. An MRI image of a healthy human finger was segmented into 7 tissue types and manipulated to create 4 models representing various degrees of RA disease activity. NIRFAST was used to simulate TD light propagation through the models at 800nm using an array of light sources/detectors placed across the proximal interphalangeal (PIP) joint. Parameters were extracted from the resulting TPSFs using statistical moments (number of photons, mean time-of-flight, centralized variance), temporal binning (early, middle, late temporal windows), and Fourier decomposition to produce a series of 2D images. Spatial frequency components were then extracted from each of the images and used to detect differences between the 4 models of disease activity. Spatial frequency amplitudes of high-frequency temporal Fourier component images differentiated between models with 100% accuracy and with the highest percent differences (i.e., performance). However, once Poisson noise was added to the TPSFs, amplitudes of early photon and total number of photon images at the 0.14mm⁻¹ spatial frequency had the highest performance for accuracy cut-offs of 95% and 100%, respectively. Future work will focus on validating results with experimental TD-DOI data and assessing how combinations of various parameters can be used to increase performance while maintaining accuracy.

Conference Presentation

Citation Download Citation

Seva Ioussoufovitch and Mamadou Diop "In silico experiments of time-resolved near-infrared light transport through human fingers with simulated rheumatoid arthritis", Proc. SPIE 11639, Optical Tomography and Spectroscopy of Tissue XIV, 116390J (5 March 2021); https://doi.org/10.1117/12.2576899

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